Bulk production and evaluation of high specific activity 186gRe for cancer therapy using enriched 186WO3 targets in a proton beam

• Published in: Nuclear medicine and biology 2017-06, Vol.49, p.24-29
• Main Authors: Mastren, Tara, Radchenko, Valery, Bach, Hong T., Balkin, Ethan R., Birnbaum, Eva R., Brugh, Mark, Engle, Jonathan W., Gott, Matthew D., Guthrie, James, Hennkens, Heather M., John, Kevin D., Ketring, Alan R., Kuchuk, Marina, Maassen, Joel R., Naranjo, Cleo M., Nortier, F. Meiring, Phelps, Tim E., Jurisson, Silvia S., Wilbur, D. Scott, Fassbender, Michael E.
• Format: Article
• Language: English
• Subjects: 186gRe; 186WO3 target; High specific activity; Radiolabeling; SPECT phantom images; Theranostic
• ISSN: 0969-8051; 1872-9614
• DOI: 10.1016/j.nucmedbio.2017.02.006

Rhenium-186g (t1/2 = 3.72 d) is a β− emitting isotope suitable for theranostic applications. Current production methods rely on reactor production by way of the reaction 185Re(n,γ)186gRe, which results in low specific activities limiting its use for cancer therapy. Production via charged particle activation of enriched 186W results in a 186gRe product with a higher specific activity, allowing it to be used more broadly for targeted radiotherapy applications. This targets the unmet clinical need for more efficient radiotherapeutics. A target consisting of highly enriched, pressed 186WO3 was irradiated with protons at the Los Alamos National Laboratory Isotope Production Facility (LANL-IPF) to evaluate 186gRe product yield and quality. LANL-IPF was operated in a dedicated nominal 40 MeV mode. Alkaline dissolution followed by anion exchange chromatography was used to isolate 186gRe from the target material. Phantom and radiolabeling studies were conducted with the produced 186gRe activity. A 186gRe batch yield of 1.38 ± 0.09 MBq/μAh or 384.9 ± 27.3 MBq/C was obtained after 16.5 h in a 205 μA average/230μA maximum current proton beam. The chemical recovery yield was 93% and radiolabeling was achieved with efficiencies ranging from 60–80%. True specific activity of 186gRe at EOB was determined via ICP-AES and amounted to 0.788 ± 0.089 GBq/μg (0.146 ± 0.017 GBq/nmol), which is approximately seven times higher than the product obtained from neutron capture in a reactor. Phantom studies show similar imaging quality to the gold standard 99mTc. We report a preliminary study of the large-scale production and novel anion exchange based chemical recovery of high specific activity 186gRe from enriched 186WO3 targets in a high-intensity proton beam with exceptional chemical recovery and radiochemical purity.