Sepsis Mimicker in an Human Immunodeficiency Virus-Infected Patient

A 22-year-old human immunodeficiency virus-infected male presented with fever, rash, hypotension, and renal insufficiency 18 days following initiation of therapy with an efavirenz-based antiretroviral regimen. Although rash is a common side effect of efavirenz, severe hypersensitivity reactions are...

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Bibliographic Details
Published in:Military medicine 2017-03, Vol.182 (3), p.e1861-e1863
Main Authors: Morgan, Mackenzie K, Hartzell, Joshua D, Blaylock, Jason M
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Anti-Retroviral Agents - pharmacology
Anti-Retroviral Agents - therapeutic use
Benzoxazines - pharmacology
Benzoxazines - therapeutic use
Drug Hypersensitivity Syndrome - complications
Drug Hypersensitivity Syndrome - diagnosis
Exanthema - etiology
Fever - etiology
HIV Infections - complications
HIV Infections - diagnosis
HIV-1 - pathogenicity
Humans
Male
Reverse Transcriptase Inhibitors - pharmacology
Reverse Transcriptase Inhibitors - therapeutic use
Tenofovir - pharmacology
Tenofovir - therapeutic use
Thrombocytopenia - etiology
Young Adult
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Description
Summary:A 22-year-old human immunodeficiency virus-infected male presented with fever, rash, hypotension, and renal insufficiency 18 days following initiation of therapy with an efavirenz-based antiretroviral regimen. Although rash is a common side effect of efavirenz, severe hypersensitivity reactions are rare. Systemic symptoms can include hepatic toxicity and pneumonitis, and in one instance death. Corticosteroids are the mainstay of treatment.
ISSN:0026-4075
1930-613X
DOI:10.7205/MILMED-D-15-00555