Effects of Ingested Crude Oil Contaminated Diets on Antioxidant Enzyme and Lipid Profile in Wistar Albino Rat

In this study, we investigated the effect of orally administered crude oil contaminated diet on some biochemical parameters of wistar rat. Twenty four (24) wistar rats weighing between 125-180g were randomly grouped into four (4) of six animals each. Each group was fed with different concentrations...

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Bibliographic Details
Published in:Journal of Applied Sciences and Environmental Management 2017-02, Vol.20 (4), p.927-927
Main Authors: OGARA, AMAECHI L, JOSHUA, PARKER E, OMEJE, KINGSLEY O, ONWURAH, IKECHUKWU N.E
Format: Article
Language:English
Subjects:
Albinism
albino rat
Cholesterol
cholesterol concentration
Crude oil
Diet
Enzymes
Food contamination & poisoning
Lipid peroxidation
Lipids
Metabolism
Metabolites
Oxidative stress
Plasma
Proteins
Rodents
superoxide dismutase
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Summary:In this study, we investigated the effect of orally administered crude oil contaminated diet on some biochemical parameters of wistar rat. Twenty four (24) wistar rats weighing between 125-180g were randomly grouped into four (4) of six animals each. Each group was fed with different concentrations of crude oil contaminated diet for 21days. At the end of each week, blood sample (2ml) was drawn from the median cantus vein of the eyes of the rats with the aid of a capillary tube and the plasma samples prepared for the biochemical tests. Also, one animal from each group was sacrificed and dissected every week; their livers were collected, weighed, washed with normal saline and later homogenized in a mortar and the isolate used for biochemical analysis. The results obtained showed the there was an increase in the weight of wet liver, lipid peroxidation and plasma protein concentration. Similarly, a time dependent increase in cholesterol concentration was obtained, with a significant decrease (p
ISSN:1119-8362
2659-1502
1119-8362
2659-1499
DOI:10.4314/jasem.v20i4.4