Correlating blood and urinary concentrations of clobazam doses in Japanese children and adolescents with intractable epilepsy

Clobazam (CLB) is an antiepileptic drug that is metabolized to the major metabolite N‐desmethylclobazam (N‐CLB). Our aim was to evaluate the utility of corrected urinary concentrations of CLB and N‐CLB in Japanese children and adolescents with epilepsy. Blood and urinary concentrations of CLB and N‐...

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Bibliographic Details
Published in:Biomedical chromatography 2017-04, Vol.31 (4), p.np-n/a
Main Authors: Iwasaki, Toshiyuki, Nonoda, Yutaka, Ishida, Tomoya, Toki, Taira, Ishii, Masahiro
Format: Article
Language:English
Subjects:
Administration, Oral
Adolescent
Anticonvulsants - administration & dosage
Anticonvulsants - blood
Anticonvulsants - urine
Asian Continental Ancestry Group
Benzodiazepines - administration & dosage
Benzodiazepines - blood
Benzodiazepines - pharmacokinetics
Benzodiazepines - urine
Child
Child, Preschool
clobazam
clobazam/N‐desmethylclobazam ratio
creatinine coefficient
Drug Resistant Epilepsy - blood
Drug Resistant Epilepsy - drug therapy
Drug Resistant Epilepsy - urine
Female
Humans
Male
N‐desmethylclobazam
urinary concentration
Young Adult
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Summary:Clobazam (CLB) is an antiepileptic drug that is metabolized to the major metabolite N‐desmethylclobazam (N‐CLB). Our aim was to evaluate the utility of corrected urinary concentrations of CLB and N‐CLB in Japanese children and adolescents with epilepsy. Blood and urinary concentrations of CLB and N‐CLB were evaluated in 42 patients. The urinary and peak blood concentrations were measured 2–3 h after the last dose. The ratio of the blood and urinary creatinine concentrations was used to calculate the corrected urinary concentrations. A moderate correlation was found between the CLB dose and the CLB serum concentration, but this correlation was not found for N‐CLB. Patients were dichotomized based on two regression lines, which were detected by statistical analyses with a cumulative distribution function: the lower ratio group (CLB/N‐CLB 
ISSN:0269-3879
1099-0801
DOI:10.1002/bmc.3848