Long-term prognostic role of CA-125 in noncongestive patients undergoing a cardiac transplantation

To evaluate the possible relationship between high levels of CA-125 and long-term prognosis in chronic heart failure patients after they undergo a cardiac transplantation (CT). We retrospectively studied all patients who underwent a CT and had a previous determination of CA-125. Congestive patients...

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Bibliographic Details
Published in:Biomarkers in medicine 2017-03, Vol.11 (3), p.239-243
Main Authors: Becerra-Muñoz, Víctor Manuel, Sobrino-Márquez, José Manuel, Rangel-Sousa, Diego, Fernández-Cisnal, Agustín, Lage-Gallé, Ernesto, García-Pinilla, José Manuel, Martínez-Martínez, Ángel, de Teresa-Galván, Eduardo
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
CA-125
CA-125 Antigen - blood
carbohydrate antigen 125
cardiac transplantation
Cardiovascular disease
Chronic obstructive pulmonary disease
Congestive heart failure
Female
Follow-Up Studies
graft rejection
Graft Rejection - diagnosis
Graft Rejection - mortality
heart failure
Heart Failure - therapy
Heart transplantation
Heart Transplantation - adverse effects
Heart transplants
Humans
Male
Middle Aged
Mortality
Odds Ratio
Ovarian cancer
Prognosis
Retrospective Studies
Survival
Survival Rate
tumor markers
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Summary:To evaluate the possible relationship between high levels of CA-125 and long-term prognosis in chronic heart failure patients after they undergo a cardiac transplantation (CT). We retrospectively studied all patients who underwent a CT and had a previous determination of CA-125. Congestive patients and those whose survival was 35 U/ml). After CT, survival was significantly inferior in this group (96.3 vs 81%, 84.9 vs 64%, 70.7 vs 32.9% at 2, 5 and 8 years, p = 0.014). CA-125 >35 U/ml was the only factor independently associated to long-term mortality (OR: 3.94; 95% CI: 1.2-12.82; p = 0.023). Noncongestive patients with high levels of CA-125 had inferior long-term survival after CT.
ISSN:1752-0363
1752-0371
DOI:10.2217/bmm-2016-0247