Optimal timing of influenza vaccination during 3‐week cytotoxic chemotherapy cycles

BACKGROUND Cytopenia occurs frequently during cytotoxic chemotherapy. Little is known about the optimal timing of influenza vaccination for patients receiving chemotherapy. This study compared the immunogenicity of an influenza vaccine administered concurrently with chemotherapy (day 1) and within t...

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Bibliographic Details
Published in:Cancer 2017-03, Vol.123 (5), p.841-848
Main Authors: Keam, Bhumsuk, Kim, Min‐Kyung, Choi, Yunhee, Choi, Su‐Jin, Choe, Pyoeng Gyun, Lee, Kyung‐Hun, Kim, Tae Min, Kim, Tae‐Yong, Oh, Do‐Youn, Kim, Dong‐Wan, Im, Seock‐Ah, Kim, Nam‐Joong, Heo, Dae Seog, Park, Wan Beom, Oh, Myoung‐don
Format: Article
Language:English
Subjects:
Aged
Breast cancer
Breast Neoplasms - complications
Breast Neoplasms - drug therapy
Breast Neoplasms - epidemiology
Breast Neoplasms - virology
Cancer
Chemotherapy
Cytopenia
Cytotoxicity
Drug Administration Schedule
Female
Hemagglutination inhibition
Humans
Immunization
Immunogenicity
Influenza
Influenza A Virus, H1N1 Subtype - drug effects
Influenza A Virus, H3N2 Subtype - drug effects
influenza vaccine
Influenza Vaccines - administration & dosage
Influenza Vaccines - adverse effects
Influenza, Human - complications
Influenza, Human - pathology
Influenza, Human - prevention & control
Lung cancer
Lung Neoplasms - complications
Lung Neoplasms - drug therapy
Lung Neoplasms - epidemiology
Lung Neoplasms - virology
Male
Middle Aged
Neoplasms - complications
Neoplasms - drug therapy
Neoplasms - pathology
Oncology
Patients
Randomization
Seroconversion
solid cancer
Vaccination
Vaccines
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Summary:BACKGROUND Cytopenia occurs frequently during cytotoxic chemotherapy. Little is known about the optimal timing of influenza vaccination for patients receiving chemotherapy. This study compared the immunogenicity of an influenza vaccine administered concurrently with chemotherapy (day 1) and within the cytopenic period (day 11) during 3‐week cytotoxic chemotherapy cycles. METHODS Adult patients with solid cancer undergoing scheduled 3‐week cytotoxic chemotherapy were randomly assigned to receive the 2014‐2015 seasonal influenza vaccine on day 1 or 11 during the chemotherapy cycle. Patients were stratified by their age (
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.30468