The Development of Psoriatic Arthritis in Patients With Psoriasis Is Preceded by a Period of Nonspecific Musculoskeletal Symptoms: A Prospective Cohort Study

Objective To assess whether the presence of nonspecific musculoskeletal symptoms, their degree, and change over time predict the development of psoriatic arthritis (PsA) in a prospective cohort of psoriasis patients without arthritis at baseline. Methods This prospective cohort study involved patien...

Full description

Saved in:
Bibliographic Details
Published in:Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2017-03, Vol.69 (3), p.622-629
Main Authors: Eder, Lihi, Polachek, Ari, Rosen, Cheryl F., Chandran, Vinod, Cook, Richard, Gladman, Dafna D.
Format: Article
Language:English
Subjects:
Arthralgia
Arthritis
Arthritis, Psoriatic - etiology
Cohort analysis
Cohort Studies
Fatigue
Fatigue - complications
Female
Hazard assessment
Health risk assessment
Humans
Male
Middle Aged
Musculoskeletal Pain - complications
Pain
Prescription drugs
Prospective Studies
Psoriasis
Psoriasis - complications
Psoriatic arthritis
Psychological stress
Signs and symptoms
Statistical models
Stiffness
Symptom Assessment
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective To assess whether the presence of nonspecific musculoskeletal symptoms, their degree, and change over time predict the development of psoriatic arthritis (PsA) in a prospective cohort of psoriasis patients without arthritis at baseline. Methods This prospective cohort study involved patients with psoriasis who were assessed at baseline to exclude the presence of clinical PsA. The study participants were reassessed annually to determine if they had developed PsA. The presence of musculoskeletal symptoms and the patients’ assessments of pain, fatigue, stiffness, physical function, and psychological distress were recorded at each visit. Cox proportional hazards models were used to assess what symptoms predicted the development of PsA. Results A total of 57 of 410 psoriasis patients developed PsA. At baseline, the presence of arthralgia in women (hazard ratio [HR] 2.59, P = 0.02), heel pain (HR 4.18, P = 0.02), high fatigue score (HR 2.36, P = 0.007), and high stiffness score (HR 2.03, P = 0.045) predicted subsequent development of PsA. In addition, an increase from baseline in fatigue score (HR 1.27, P = 0.001), pain score (HR 1.34, P 
ISSN:2326-5191
2326-5205
DOI:10.1002/art.39973