The genomes of three North American orthopoxviruses

The complete genomes of a skunkpox, volepox, and raccoonpox virus were sequenced and annotated. Phylogenetic analysis of these genomes indicates that although these viruses are all orthopoxviruses , they form a distinct clade to the other known species. This supports the ancient divergence of the No...

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Bibliographic Details
Published in:Virus genes 2017-02, Vol.53 (1), p.21-34
Main Authors: Smithson, Chad, Tang, Nick, Sammons, Scott, Frace, Mike, Batra, Dhwani, Li, Yu, Emerson, Ginny L., Carroll, Darin S., Upton, Chris
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Computational Biology - methods
Disease
Divergence
Gene Expression Regulation, Viral
Genes
Genome, Viral
Genomes
Humans
Medical Microbiology
Molecular Sequence Annotation
Mutation
North America - epidemiology
Open Reading Frames
Orthopoxvirus - classification
Orthopoxvirus - genetics
Phylogenetics
Phylogeny
Plant Sciences
Poxviridae
Poxviridae Infections - epidemiology
Poxviridae Infections - virology
Rabies
Sequence Analysis, DNA
Smallpox
Vaccines
Virology
Viruses
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Summary:The complete genomes of a skunkpox, volepox, and raccoonpox virus were sequenced and annotated. Phylogenetic analysis of these genomes indicates that although these viruses are all orthopoxviruses , they form a distinct clade to the other known species. This supports the ancient divergence of the North American orthopoxviruses from other members of the orthopoxviruses . Only two open reading frames appear to be unique to this group of viruses, but a relatively small number of insertions/deletions contribute to the varied gene content of this clade. The availability of these genomes will help determine whether skunkpox and volepox viruses share the characteristics that make raccoonpox a useful vaccine vector.
ISSN:0920-8569
1572-994X
DOI:10.1007/s11262-016-1388-9