Elevated Serum Brain-Derived Neurotrophic Factor (BDNF) but not BDNF Gene Val66Met Polymorphism Is Associated with Autism Spectrum Disorders

The aim of our study was to illuminate the potential role of brain-derived neurotrophic factor (BDNF) in autism spectrum disorder (ASD). We measured the circulating levels of BDNF in serum and BDNF gene (Val66Met) polymorphisms, in which two indicators were then compared between ASD and normal contr...

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Bibliographic Details
Published in:Molecular neurobiology 2017-03, Vol.54 (2), p.1167-1172
Main Authors: Meng, Wei-Dong, Sun, Shao-Jun, Yang, Jie, Chu, Rui-Xue, Tu, Wenjun, Liu, Qiang
Format: Article
Language:English
Subjects:
Autism
Autism Spectrum Disorder - blood
Autism Spectrum Disorder - diagnosis
Autism Spectrum Disorder - genetics
Biomarkers
Biomarkers - blood
Biomedical and Life Sciences
Biomedicine
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - blood
Brain-Derived Neurotrophic Factor - genetics
Case-Control Studies
Cell Biology
Child
Child, Preschool
Female
Genetic Association Studies - methods
Humans
Male
Methionine - genetics
Neurobiology
Neurology
Neurosciences
Polymorphism
Polymorphism, Genetic - physiology
Valine - genetics
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Summary:The aim of our study was to illuminate the potential role of brain-derived neurotrophic factor (BDNF) in autism spectrum disorder (ASD). We measured the circulating levels of BDNF in serum and BDNF gene (Val66Met) polymorphisms, in which two indicators were then compared between ASD and normal controls. A total of 82 drug-naïve ASD children and 82 age- and gender-matched normal controls were enrolled in the study. Their serum BDNF levels were detected by the ELISA. BDNF Val66Met polymorphism genotyping was conducted as according to the laboratory’s standard protocol in laboratory. The ASD severity assessment was mainly determined by the score of the Childhood Autism Rating Scale (CARS). ELISA assay showed that the mean serum BDNF level of children with ASD was significantly ( P  
ISSN:0893-7648
1559-1182
DOI:10.1007/s12035-016-9721-9