Correlation of intratumoral lymphatic microvessel density, vascular endothelial growth factor C and cell proliferation in salivary gland tumors

Lymphatic dissemination is one of the most important pathways for metastasis in many solid tumors, including head and neck carcinomas. The lymphatic growth of cancer has been used as a significant independent adverse prognostic factor and provides information about tumor progression. Salivary gland...

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Bibliographic Details
Published in:Medical molecular morphology 2017-03, Vol.50 (1), p.17-24
Main Authors: Americo, Márcia Gimenes, Marques, Yonara Maria Freire Soares, El Abras Ankha, Milagros Del Valle, do Prado, Renata Falchete, Carvalho, Yasmin Rodarte
Format: Article
Language:English
Subjects:
Anatomy
Antibodies, Monoclonal, Murine-Derived - metabolism
Biomarkers, Tumor - metabolism
Cell adhesion & migration
Cell Proliferation
Correlation analysis
Endothelium
Humans
Immunohistochemistry
Ki-67 Antigen - metabolism
Lymphatic system
Lymphatic Vessels - blood supply
Lymphatic Vessels - pathology
Medicine
Medicine & Public Health
Microvessels - pathology
Molecular Medicine
Original Paper
Pathology
Salivary Gland Neoplasms - blood supply
Salivary Gland Neoplasms - pathology
Tumors
Vascular Endothelial Growth Factor C - metabolism
Veins & arteries
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Summary:Lymphatic dissemination is one of the most important pathways for metastasis in many solid tumors, including head and neck carcinomas. The lymphatic growth of cancer has been used as a significant independent adverse prognostic factor and provides information about tumor progression. Salivary gland tumors present different prognoses and have the ability to develop metastases; however, this information regarding the lymphatic spread is scarce. This paper quantifies the lymphatic microvessel density (LMD) in benign and malignant salivary gland tumors and analyzes the relationship between LMD and tumor expression of vascular endothelial growth factors C (VEGF-C) and the proliferative index. The results show that there is no correlation between LMD, VEGF-C and the proliferative index in the majority of salivary gland tumors analyzed, apart from polymorphous low-grade carcinoma which exhibits statistical correlation between LMD and the proliferative index ( p  
ISSN:1860-1480
1860-1499
DOI:10.1007/s00795-016-0142-7