ANTISTAPHYBASE: database of antimicrobial peptides (AMPs) and essential oils (EOs) against methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus

• Published in: Archives of microbiology 2017-03, Vol.199 (2), p.215-222
• Main Authors: Zouhir, Abdelmajid, Taieb, Malek, Lamine, Mohamed Ashraf, Cherif, Ammar, Jridi, Taoufik, Mahjoubi, Basma, Mbarek, Sarra, Fliss, Ismail, Nefzi, Adel, Sebei, Khaled, Ben Hamida, Jeannette
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antimicrobial agents; Bacteria; Biochemistry; Biomedical and Life Sciences; Biotechnology; Cell Biology; Databases, Pharmaceutical; Ecology; Essential oils; Life Sciences; Methicillin-Resistant Staphylococcus aureus - drug effects; Microbial Ecology; Microbiology; Microorganisms; Nosocomial infections; Oils & fats; Oils, Volatile - pharmacology; Original Paper; Pathogens; Peptides; Peptides - chemistry; Peptides - pharmacology; Physicochemical properties; Staphylococcus aureus; Staphylococcus aureus - drug effects; Staphylococcus infections; Structure-Activity Relationship
• ISSN: 0302-8933; 1432-072X
• DOI: 10.1007/s00203-016-1293-6

Staphylococcus aureus and methicillin-resistant S . aureus are major pathogens. The antimicrobial peptides and essential oils (EOs) display narrow- or broad-spectrum activity against bacteria including these strains. A centralized resource, such as a database, designed specifically for anti- S . aureus /anti-methicillin-resistant S . aureus antimicrobial peptides and EOs is therefore needed to facilitate the comprehensive investigation of their structure/activity associations and combinations. The database ANTISTAPHYBASE is created to facilitate access to important information on antimicrobial peptides and essential peptides against methicillin-resistant S . aureus and S . aureus . At the moment, the database contains 596 sequences of antimicrobial peptides produced by diverse organisms and 287 essential oil records. It permits a quick and easy search of peptides based on their activity as well as their general, physicochemical properties and literature data. These data are very useful to perform further bioinformatic or chemometric analysis and would certainly be useful for the development of new drugs for medical use. The ANTISTAPHYBASE database is freely available at: https://www.antistaphybase.com/ .