Regional citrate anticoagulation for continuous renal replacement therapy in children

Background Anticoagulation of the continuous renal replacement therapy (CRRT) circuit is an important technical aspect of this medical procedure. Most studies evaluating the efficacy and safety of citrate use have been carried out in adults, and little evidence is available for the pediatric patient...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2017-04, Vol.32 (4), p.703-711
Main Authors: Rico, Mayerly Prada, Fernández Sarmiento, Jaime, Rojas Velasquez, Ana María, González Chaparro, Luz Stella, Gastelbondo Amaya, Ricardo, Mulett Hoyos, Hernando, Tibaduiza, Daniel, Quintero Gómez, Ana Maria
Format: Article
Language:English
Subjects:
Acute Kidney Injury - therapy
Adolescent
Anticoagulants
Anticoagulants - adverse effects
Anticoagulants - therapeutic use
Blood Coagulation - drug effects
Child
Child, Preschool
Citric Acid - adverse effects
Citric Acid - therapeutic use
Cohort analysis
Cohort Studies
Critical Care
Female
Gastroenterology
Hemofiltration - instrumentation
Hemofiltration - methods
Hemorrhage - chemically induced
Hemorrhage - epidemiology
Heparin - adverse effects
Heparin - therapeutic use
Humans
Infant
Male
Medicine
Medicine & Public Health
Metabolism
Nephrology
Original Article
Patients
Pediatrics
Renal replacement therapy
Renal Replacement Therapy - methods
Retrospective Studies
Urology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Anticoagulation of the continuous renal replacement therapy (CRRT) circuit is an important technical aspect of this medical procedure. Most studies evaluating the efficacy and safety of citrate use have been carried out in adults, and little evidence is available for the pediatric patient population. The aim of this study was to compare regional citrate anticoagulation versus systemic heparin anticoagulation in terms of the lifetime of hemofilters in a pediatric population receiving CRRT at a pediatric center in Bogota, Colombia. Methods This was an analytical, observational, retrospective cohort study in which we assessed the survival of 150 hemofilters (citrate group 80 hemofilters, heparin group 70 hemofilters) used in a total of 3442 hours of CCRT (citrate group 2248 h, heparin group 1194 h). Hemofilter survival was estimated beginning at placement and continuing until filter replacement due to clotting or high trans-membrane pressures. Results Hemofilter survival was higher in the citrate group than in the heparin group (72 vs. 18 h; p
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-016-3544-9