Adjuvant chemotherapy versus chemoradiotherapy in the management of patients with surgically resected duodenal adenocarcinoma: A propensity score‐matched analysis of a nationwide clinical oncology database

BACKGROUND To the authors' knowledge, optimal adjuvant approaches for resected duodenal adenocarcinoma are not well established. Given the significant risk of locoregional disease recurrence, there may be a subset of patients who demonstrate an improvement in overall survival (OS) from the addi...

Full description

Saved in:
Bibliographic Details
Published in:Cancer 2017-03, Vol.123 (6), p.967-976
Main Authors: Ecker, Brett L., McMillan, Matthew T., Datta, Jashodeep, Lee, Major K., Karakousis, Giorgos C., Vollmer, Charles M., Drebin, Jeffrey A., Fraker, Douglas L., Roses, Robert E.
Format: Article
Language:English
Subjects:
Adenocarcinoma
Adenocarcinoma - diagnosis
Adenocarcinoma - epidemiology
Adenocarcinoma - mortality
Adenocarcinoma - therapy
adjuvant therapy
Aged
Aged, 80 and over
Cancer
Cancer therapies
Chemoradiotherapy
Chemoradiotherapy, Adjuvant
Chemotherapy
Chemotherapy, Adjuvant
Classification
Colorectal cancer
Combined Modality Therapy
Comorbidity
Confidence intervals
Databases, Factual
Disease Management
duodenal cancer
Duodenal Neoplasms - diagnosis
Duodenal Neoplasms - epidemiology
Duodenal Neoplasms - mortality
Duodenal Neoplasms - therapy
Female
Health risks
Histology
Humans
Lymph
Lymph nodes
Lymphatic system
Male
Middle Aged
Neoplasm Grading
Neoplasm Metastasis
Neoplasm Staging
Oncology
Patients
Propensity Score
Proportional Hazards Models
Radiation
Radiation therapy
radiotherapy
Regression analysis
small bowel cancer
Small intestine
Surgery
Survival
Treatment Outcome
United States - epidemiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BACKGROUND To the authors' knowledge, optimal adjuvant approaches for resected duodenal adenocarcinoma are not well established. Given the significant risk of locoregional disease recurrence, there may be a subset of patients who demonstrate an improvement in overall survival (OS) from the addition of radiotherapy (chemoradiotherapy [CRT]) to an adjuvant chemotherapy regimen. METHODS Patients with resected, nonmetastatic duodenal adenocarcinoma who received chemotherapy (694 patients) or CRT (550 patients) were identified in the National Cancer Data Base (1998‐2012). Cox regression identified covariates associated with OS. The chemotherapy and CRT cohorts were matched (1:1) by propensity scores based on the likelihood of receiving CRT or the survival hazard from Cox modeling. OS was compared using Kaplan‐Meier estimates. RESULTS CRT was more frequently used for patients who underwent positive‐margin surgical resection (15.9% vs 9.1%; P
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.30439