Cardiorespiratory fitness and incident heart failure: The Henry Ford ExercIse Testing (FIT) Project

Prior studies have demonstrated cardiorespiratory fitness (CRF) to be a strong marker of cardiovascular health. However, there are limited data investigating the association between CRF and risk of progression to heart failure (HF). The purpose of this study was to determine the relationship between...

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Bibliographic Details
Published in:The American heart journal 2017-03, Vol.185, p.35-42
Main Authors: Kupsky, Daniel F., Ahmed, Amjad M., Sakr, Sherif, Qureshi, Waqas T., Brawner, Clinton A., Blaha, Michael J., Ehrman, Jonathan K., Keteyian, Steven J., Al-Mallah, Mouaz H.
Format: Article
Language:English
Subjects:
Adult
Aged
Atrial Fibrillation - epidemiology
Cardiac arrhythmia
Cardiorespiratory Fitness
Cardiovascular disease
Cohort Studies
Comorbidity
Coronary artery
Coronary artery disease
Coronary Artery Disease - epidemiology
Coronary vessels
Diabetes
Diabetes Mellitus - epidemiology
Electronic health records
Electronic medical records
Exercise
Exercise Test
Family medical history
Female
Fitness
Fitness equipment
Fitness training programs
Hazards
Health hazards
Health risk assessment
Heart
Heart attacks
Heart diseases
Heart failure
Heart Failure - epidemiology
Heart rate
Hospital systems
Humans
Hypertension
Hypertension - epidemiology
Incidence
Male
Medical electronics
Medical prognosis
Mens health
Metabolic Equivalent
Metabolism
Michigan - epidemiology
Middle Aged
Myocardial Infarction - epidemiology
Obesity - epidemiology
Patients
Physical fitness
Population
Prevalence
Proportional Hazards Models
Retrospective Studies
Risk
Risk analysis
Risk Factors
Sedentary Lifestyle
Statistical models
Studies
Workloads
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Summary:Prior studies have demonstrated cardiorespiratory fitness (CRF) to be a strong marker of cardiovascular health. However, there are limited data investigating the association between CRF and risk of progression to heart failure (HF). The purpose of this study was to determine the relationship between CRF and incident HF. We included 66,329 patients (53.8% men, mean age 55 years) free of HF who underwent exercise treadmill stress testing at Henry Ford Health Systems between 1991 and 2009. Incident HF was determined using International Classification of Diseases, Ninth Revision codes from electronic medical records or administrative claim files. Cox proportional hazards models were performed to determine the association between CRF and incident HF. A total of 4,652 patients developed HF after a median follow-up duration of 6.8 (±3) years. Patients with incident HF were older (63 vs 54 years, P
ISSN:0002-8703
1097-6744
DOI:10.1016/j.ahj.2016.12.006