Pioneering medical advances through nanofluidic implantable technologies

Nanofluidic implantables represent a recent advance in a broad effort for developing personalized, point‐of‐care medical technologies. Such systems have unprecedented potential when matched with the newest developments in robotics, microprocessing, and tissue engineering. In this review, we present...

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Bibliographic Details
Published in:Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 2017-09, Vol.9 (5), p.e1455-n/a
Main Authors: Hood, R. Lyle, Hood, Gold Darr, Ferrari, Mauro, Grattoni, Alessandro
Format: Article
Language:English
Subjects:
Biosensors
Drug discovery
Fluidics
Humans
Microfluidics
Nanofluids
Nanotechnology
Precision medicine
Prostheses and Implants
Robotic surgery
Robotics
Tissue engineering
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Summary:Nanofluidic implantables represent a recent advance in a broad effort for developing personalized, point‐of‐care medical technologies. Such systems have unprecedented potential when matched with the newest developments in robotics, microprocessing, and tissue engineering. In this review, we present their emergence in medicine within the fields of diagnostics, biosensing, therapeutics, and theranostics. Discussion includes current limitations and future directions for these systems, as commensurate advances in power density and electronic processing are continually redefining the possible. As the research and funding attention coincide with complementary technological breakthroughs, the field is expected to grow into an advanced toolset for preserving human health. WIREs Nanomed Nanobiotechnol 2017, 9:e1455. doi: 10.1002/wnan.1455 This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Implantable Materials and Surgical Technologies > Nanomaterials and Implants a) Render of a next‐generation, nanofluidic implantable system capable of active controlled delivery. (b and c) Illustration of how ion concentration polarization (ICP) is employed for active control. (d) Graph of dendritic fullerene 1 release modulation over 2 days. Interruption was accomplished with both bias directions.
ISSN:1939-5116
1939-0041
DOI:10.1002/wnan.1455