The accumulation of regulatory T cells in the hepatic hilar lymph nodes in biliary atresia

Purpose A proposed etiopathogenesis of biliary atresia (BA) involves T-cell-mediated inflammatory bile duct damage and progressive hepatic fibrosis. Pediatric surgeons often observe swelling of the hepatic hilar lymph nodes during the Kasai procedure. Given the importance of regulatory mechanisms in...

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Bibliographic Details
Published in:Surgery today (Tokyo, Japan) Japan), 2017-10, Vol.47 (10), p.1282-1286
Main Authors: Sakamoto, Naoya, Muraji, Toshihiro, Ohtani, Haruo, Masumoto, Kouji
Format: Article
Language:English
Subjects:
Adolescent
Bile Ducts - immunology
Bile Ducts - pathology
Biliary Atresia - blood
Biliary Atresia - etiology
Biliary Atresia - immunology
Biliary Atresia - pathology
CD4-Positive T-Lymphocytes
Child
Child, Preschool
Female
Humans
Infant
Liver - immunology
Liver - pathology
Lymph Nodes - immunology
Lymph Nodes - pathology
Male
Medicine
Medicine & Public Health
Original Article
Portoenterostomy, Hepatic
Prospective Studies
Surgery
Surgical Oncology
T-Lymphocytes, Regulatory - immunology
T-Lymphocytes, Regulatory - pathology
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Summary:Purpose A proposed etiopathogenesis of biliary atresia (BA) involves T-cell-mediated inflammatory bile duct damage and progressive hepatic fibrosis. Pediatric surgeons often observe swelling of the hepatic hilar lymph nodes during the Kasai procedure. Given the importance of regulatory mechanisms in immune responses, the present study was designed to analyze the quantitative changes of regulatory T cells ( T reg cells) in the hepatic hilar lymph nodes (hepatic hilar LNs) and peripheral blood (PB) in BA. Methods The hepatic hilar LNs and PB obtained during the Kasai procedure were analyzed by flow cytometry. The ratios of total and active Tregs to the total CD4 + cells in the PB and the hepatic hilar LNs were compared. Results In patients with BA, the ratios of both the total and active T reg cells in the hepatic hilar LNs were higher than those in the PB (total T reg cells: PB vs. LN; P  
ISSN:0941-1291
1436-2813
DOI:10.1007/s00595-017-1502-1