HIV-associated neurodegeneration and neuroimmunity: multivoxel MR spectroscopy study in drug-naïve and treated patients

Objectives The aim of this study was to test neurobiochemical changes in normal appearing brain tissue in HIV+ patients receiving and not receiving combined antiretroviral therapy (cART) and healthy controls, using multivoxel MR spectroscopy (mvMRS). Methods We performed long- and short-echo 3D mvMR...

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Bibliographic Details
Published in:European radiology 2017-10, Vol.27 (10), p.4218-4236
Main Authors: Boban, Jasmina, Kozic, Dusko, Turkulov, Vesna, Ostojic, Jelena, Semnic, Robert, Lendak, Dajana, Brkic, Snezana
Format: Article
Language:English
Subjects:
Adult
AIDS Dementia Complex - diagnostic imaging
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Aspartic Acid - analysis
Biomarkers - analysis
Brain
Brain - diagnostic imaging
Brain - metabolism
Case-Control Studies
Choline - analysis
Creatine - analysis
Dementia
Diagnostic Radiology
Female
HIV Infections - complications
Humans
Imaging
Internal Medicine
Interventional Radiology
Magnetic resonance spectroscopy
Magnetic Resonance Spectroscopy - methods
Male
Medicine
Medicine & Public Health
Middle Aged
Neuro
Neurodegeneration
Neurodegenerative Diseases - diagnostic imaging
Neurodegenerative Diseases - etiology
Neuroradiology
Patients
Radiology
Retrospective Studies
Spectroscopic analysis
Spectroscopy
Spectrum analysis
Substantia alba
Therapy
Ultrasound
White Matter - diagnostic imaging
Young Adult
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Summary:Objectives The aim of this study was to test neurobiochemical changes in normal appearing brain tissue in HIV+ patients receiving and not receiving combined antiretroviral therapy (cART) and healthy controls, using multivoxel MR spectroscopy (mvMRS). Methods We performed long- and short-echo 3D mvMRS in 110 neuroasymptomatic subjects (32 HIV+ subjects on cART, 28 HIV+ therapy-naïve subjects and 50 healthy controls) on a 3T MR scanner, targeting frontal and parietal supracallosal subcortical and deep white matter and cingulate gyrus (NAA/Cr, Cho/Cr and mI/Cr ratios were analysed). The statistical value was set at p 
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-017-4772-5