Localization of VZV in saliva of zoster patients

Varicella zoster virus (VZV) in saliva from six herpes zoster patients and one chickenpox patient was found to be exclusively associated with epithelial cells by confocal microscopy. VZV localization with antibody specific to the VZV glycoprotein E was detected primarily on the membrane but was also...

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Bibliographic Details
Published in:Journal of medical virology 2017-09, Vol.89 (9), p.1686-1689
Main Authors: Mehta, Satish K., Nelman‐Gonzalez, Mayra, Tyring, Stephen K., Tong, Yun, Beitman, Andrew, Crucian, Brian E., Renner, Ashlie N., Pierson, Duane L.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Epithelial Cells - virology
Female
Herpes Zoster - virology
herpesvirus
Herpesvirus 3, Human - isolation & purification
Humans
infection
Male
Microscopy, Confocal
Middle Aged
Polymerase Chain Reaction
reactivation
Saliva - virology
varicella‐zoster virus
virus classification
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Summary:Varicella zoster virus (VZV) in saliva from six herpes zoster patients and one chickenpox patient was found to be exclusively associated with epithelial cells by confocal microscopy. VZV localization with antibody specific to the VZV glycoprotein E was detected primarily on the membrane but was also inside the cell. Epithelial cells with VZV were still present in saliva in one out of two tested zoster patients after 10 months of recovery. Saliva from healthy controls (non‐shingles patients, n = 5) did not show any sign of VZV by polymerase chain reaction or by confocal microscopy. No VZV was found in the liquid fraction of saliva. Further work is required to understand the movement of VZV in the saliva cells of infected patients.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.24807