Neural tube closure and embryonic metabolism

Neural tube closure (NTC) is an embryonic process during formation of the mammalian central nervous system. Disruption of the dynamic, sequential events of NTC can cause neural tube defects (NTD) leading to spina bifida and anencephaly in the newborn. NTC is affected by inherent factors such as gene...

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Bibliographic Details
Published in:Congenital anomalies 2017-09, Vol.57 (5), p.134-137
Main Authors: Yamaguchi, Yoshifumi, Miyazawa, Hidenobu, Miura, Masayuki
Format: Article
Language:English
Subjects:
Anencephaly - etiology
Anencephaly - metabolism
Anencephaly - pathology
Animals
Central nervous system
Chorioallantoic Membrane - metabolism
Chorioallantoic Membrane - pathology
Disruption
Embryo, Mammalian
Embryos
energy metabolism
Energy Metabolism - physiology
Etiology
Female
Glucose - metabolism
Humans
Infant, Newborn
Mass spectrometry
Maternal Exposure - adverse effects
Maternal-Fetal Exchange - physiology
maternal‐fetal interaction
Metabolism
Metabolites
Metabolome
Mutation
Neural Tube - abnormalities
Neural Tube - embryology
Neural Tube - metabolism
neural tube closure
neural tube defects
Nutrients
Organic chemistry
placentation
Pregnancy
Rewiring
Spinal Dysraphism - etiology
Spinal Dysraphism - metabolism
Spinal Dysraphism - pathology
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Summary:Neural tube closure (NTC) is an embryonic process during formation of the mammalian central nervous system. Disruption of the dynamic, sequential events of NTC can cause neural tube defects (NTD) leading to spina bifida and anencephaly in the newborn. NTC is affected by inherent factors such as genetic mutation or if the mother is exposed to certain environmental factors such as intake of harmful chemicals, maternal infection, irradiation, malnutrition, and inadequate or excessive intake of specific nutrients. Although effects of these stress factors on NTC have been intensively studied, the metabolic state of a normally developing embryo remains unclear. State‐of‐the art mass spectrometry techniques have enabled detailed study of embryonic metabolite profiles and their distribution within tissues. This approach has demonstrated that glucose metabolism is altered during NTC stages involving chorioallantoic branching. An understanding of embryonic metabolic rewiring would help reveal the etiology of NTD caused by environmental factors.
ISSN:0914-3505
1741-4520
DOI:10.1111/cga.12219