Epigenetics of Atherosclerosis: Emerging Mechanisms and Methods

Atherosclerosis is a vascular pathology characterized by inflammation and plaque build-up within arterial vessel walls. Vessel occlusion, often occurring after plaque rupture, can result in myocardial and cerebral infarction. Epigenetic changes are increasingly being associated with atherosclerosis...

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Bibliographic Details
Published in:Trends in molecular medicine 2017-04, Vol.23 (4), p.332-347
Main Authors: Khyzha, Nadiya, Alizada, Azad, Wilson, Michael D, Fish, Jason E
Format: Article
Language:English
Subjects:
Animals
atherosclerosis
Atherosclerosis - genetics
Atherosclerosis - immunology
DNA Methylation
endothelial
Epigenesis, Genetic
epigenetics
Genomics
Histone Code
Humans
inflammation
Inflammation - genetics
Inflammation - immunology
NF-kappa B - genetics
NF-kappa B - immunology
Pathology
Protein Processing, Post-Translational
RNA, Long Noncoding - genetics
RNA, Long Noncoding - immunology
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Summary:Atherosclerosis is a vascular pathology characterized by inflammation and plaque build-up within arterial vessel walls. Vessel occlusion, often occurring after plaque rupture, can result in myocardial and cerebral infarction. Epigenetic changes are increasingly being associated with atherosclerosis and are of interest from both therapeutic and biomarker perspectives. Emerging genomic approaches that profile DNA methylation, chromatin accessibility, post-translational histone modifications, transcription factor binding, and RNA expression in low or single cell populations are poised to enhance our spatiotemporal understanding of atherogenesis. Here, we review recent therapeutically relevant epigenetic discoveries and emerging technologies that may generate new opportunities for atherosclerosis research.
ISSN:1471-4914
1471-499X
DOI:10.1016/j.molmed.2017.02.004