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Epigenetics of Atherosclerosis: Emerging Mechanisms and Methods

Atherosclerosis is a vascular pathology characterized by inflammation and plaque build-up within arterial vessel walls. Vessel occlusion, often occurring after plaque rupture, can result in myocardial and cerebral infarction. Epigenetic changes are increasingly being associated with atherosclerosis...

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Published in:	Trends in molecular medicine 2017-04, Vol.23 (4), p.332-347
Main Authors:	Khyzha, Nadiya, Alizada, Azad, Wilson, Michael D, Fish, Jason E
Format:	Article
Language:	English
Subjects:	Animals atherosclerosis Atherosclerosis - genetics Atherosclerosis - immunology DNA Methylation endothelial Epigenesis, Genetic epigenetics Genomics Histone Code Humans inflammation Inflammation - genetics Inflammation - immunology NF-kappa B - genetics NF-kappa B - immunology Pathology Protein Processing, Post-Translational RNA, Long Noncoding - genetics RNA, Long Noncoding - immunology transcription
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creator	Khyzha, Nadiya Alizada, Azad Wilson, Michael D Fish, Jason E
description	Atherosclerosis is a vascular pathology characterized by inflammation and plaque build-up within arterial vessel walls. Vessel occlusion, often occurring after plaque rupture, can result in myocardial and cerebral infarction. Epigenetic changes are increasingly being associated with atherosclerosis and are of interest from both therapeutic and biomarker perspectives. Emerging genomic approaches that profile DNA methylation, chromatin accessibility, post-translational histone modifications, transcription factor binding, and RNA expression in low or single cell populations are poised to enhance our spatiotemporal understanding of atherogenesis. Here, we review recent therapeutically relevant epigenetic discoveries and emerging technologies that may generate new opportunities for atherosclerosis research.
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subjects	Animals atherosclerosis Atherosclerosis - genetics Atherosclerosis - immunology DNA Methylation endothelial Epigenesis, Genetic epigenetics Genomics Histone Code Humans inflammation Inflammation - genetics Inflammation - immunology NF-kappa B - genetics NF-kappa B - immunology Pathology Protein Processing, Post-Translational RNA, Long Noncoding - genetics RNA, Long Noncoding - immunology transcription
title	Epigenetics of Atherosclerosis: Emerging Mechanisms and Methods
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