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Neopterin as a new biomarker for the evaluation of occupational exposure to silica
Silica is one of the most documented workplace contaminants. Long-term occupational exposure to silica is associated with an increased risk for respiratory diseases such as silicosis, tuberculosis, chronic bronchitis, chronic obstructive pulmonary disease and lung cancer. Furthermore, a variety of i...
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| Published in: | International archives of occupational and environmental health 2003-05, Vol.76 (4), p.318-322 |
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| creator | ALTINDAG, Zeynep Zubeyde BAYDAR, Terken ISIMER, Askin SAHIN, Gonul |
| description | Silica is one of the most documented workplace contaminants. Long-term occupational exposure to silica is associated with an increased risk for respiratory diseases such as silicosis, tuberculosis, chronic bronchitis, chronic obstructive pulmonary disease and lung cancer. Furthermore, a variety of immune-dysfunction-related diseases has been reported in silicotic individuals. Preliminary studies indicating enhanced levels of autoantibodies and several cytokines reflect an involvement of the immune system in the pathogenesis of silicosis and resulting complications. As an early and valuable biomarker of cellular immunity, neopterin is a low-molecular-mass compound belonging to the class of pteridines. It is produced by guanosine triphosphate via interferon-gamma, following the activation of T cells. The aim of the present study was to observe the alteration of neopterin in silica exposure, and also to show whether screening of neopterin levels may be of use for assessment of occupational exposure to silica.
In this study, serum and urinary neopterin levels, both in silica-exposed workers ( n=22) and healthy volunteers ( n=20), were investigated by ELISA, spectrophotometry and HPLC techniques.
Serum neopterin levels of control and exposed groups were measured as 5.98+ or -0.44 and 7.86+ or -1.97 nmol/l, respectively ( P |
| doi_str_mv | 10.1007/s00420-003-0434-9 |
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In this study, serum and urinary neopterin levels, both in silica-exposed workers ( n=22) and healthy volunteers ( n=20), were investigated by ELISA, spectrophotometry and HPLC techniques.
Serum neopterin levels of control and exposed groups were measured as 5.98+ or -0.44 and 7.86+ or -1.97 nmol/l, respectively ( P<0.05). Urinary neopterin levels were also increased in the exposed group: 97.60+ or -41.42 micromol/mol creatinine for controls and 165.59+/-78.20 micromol/mol creatinine for workers ( P<0.05). At the same time, the correlation between urinary neopterin levels, serum neopterin concentration and working years, smoking status, some complaints, and silica status in the working atmosphere were evaluated.
Our findings suggest that the following up of neopterin levels may have diagnostic value in silica-related diseases such as silicosis. Moreover, its biological monitoring should be performed in workplaces for clinical diagnosis and prognosis.</description><identifier>ISSN: 0340-0131</identifier><identifier>EISSN: 1432-1246</identifier><identifier>DOI: 10.1007/s00420-003-0434-9</identifier><identifier>PMID: 12768284</identifier><identifier>CODEN: IAEHDW</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Adult ; Air Pollutants, Occupational - adverse effects ; Biological and medical sciences ; Biomarkers ; Biomarkers - blood ; Biomarkers - urine ; Biomonitoring ; Chemical and industrial products toxicology. Toxic occupational diseases ; Chronic obstructive pulmonary disease ; Contaminants ; Humans ; Immune system ; Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.) ; Liquid chromatography ; Lung cancer ; Lung Diseases - chemically induced ; Lung Diseases - diagnosis ; Male ; Medical sciences ; Neopterin - blood ; Neopterin - urine ; Occupational Diseases - chemically induced ; Occupational Diseases - diagnosis ; Occupational exposure ; Occupational hazards ; Respiratory diseases ; Risk exposure ; Silica ; Silicon Dioxide - adverse effects ; Silicosis ; Spectrophotometry ; Toxicology</subject><ispartof>International archives of occupational and environmental health, 2003-05, Vol.76 (4), p.318-322</ispartof><rights>2003 INIST-CNRS</rights><rights>Springer-Verlag 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-1a5f85332ac2f09e9afef870400b57ce351558b4de0193fddf468ecf8c9ffe1d3</citedby><cites>FETCH-LOGICAL-c451t-1a5f85332ac2f09e9afef870400b57ce351558b4de0193fddf468ecf8c9ffe1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14888214$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12768284$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ALTINDAG, Zeynep Zubeyde</creatorcontrib><creatorcontrib>BAYDAR, Terken</creatorcontrib><creatorcontrib>ISIMER, Askin</creatorcontrib><creatorcontrib>SAHIN, Gonul</creatorcontrib><title>Neopterin as a new biomarker for the evaluation of occupational exposure to silica</title><title>International archives of occupational and environmental health</title><addtitle>Int Arch Occup Environ Health</addtitle><description>Silica is one of the most documented workplace contaminants. Long-term occupational exposure to silica is associated with an increased risk for respiratory diseases such as silicosis, tuberculosis, chronic bronchitis, chronic obstructive pulmonary disease and lung cancer. Furthermore, a variety of immune-dysfunction-related diseases has been reported in silicotic individuals. Preliminary studies indicating enhanced levels of autoantibodies and several cytokines reflect an involvement of the immune system in the pathogenesis of silicosis and resulting complications. As an early and valuable biomarker of cellular immunity, neopterin is a low-molecular-mass compound belonging to the class of pteridines. It is produced by guanosine triphosphate via interferon-gamma, following the activation of T cells. The aim of the present study was to observe the alteration of neopterin in silica exposure, and also to show whether screening of neopterin levels may be of use for assessment of occupational exposure to silica.
In this study, serum and urinary neopterin levels, both in silica-exposed workers ( n=22) and healthy volunteers ( n=20), were investigated by ELISA, spectrophotometry and HPLC techniques.
Serum neopterin levels of control and exposed groups were measured as 5.98+ or -0.44 and 7.86+ or -1.97 nmol/l, respectively ( P<0.05). Urinary neopterin levels were also increased in the exposed group: 97.60+ or -41.42 micromol/mol creatinine for controls and 165.59+/-78.20 micromol/mol creatinine for workers ( P<0.05). At the same time, the correlation between urinary neopterin levels, serum neopterin concentration and working years, smoking status, some complaints, and silica status in the working atmosphere were evaluated.
Our findings suggest that the following up of neopterin levels may have diagnostic value in silica-related diseases such as silicosis. Moreover, its biological monitoring should be performed in workplaces for clinical diagnosis and prognosis.</description><subject>Adult</subject><subject>Air Pollutants, Occupational - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - urine</subject><subject>Biomonitoring</subject><subject>Chemical and industrial products toxicology. 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Long-term occupational exposure to silica is associated with an increased risk for respiratory diseases such as silicosis, tuberculosis, chronic bronchitis, chronic obstructive pulmonary disease and lung cancer. Furthermore, a variety of immune-dysfunction-related diseases has been reported in silicotic individuals. Preliminary studies indicating enhanced levels of autoantibodies and several cytokines reflect an involvement of the immune system in the pathogenesis of silicosis and resulting complications. As an early and valuable biomarker of cellular immunity, neopterin is a low-molecular-mass compound belonging to the class of pteridines. It is produced by guanosine triphosphate via interferon-gamma, following the activation of T cells. The aim of the present study was to observe the alteration of neopterin in silica exposure, and also to show whether screening of neopterin levels may be of use for assessment of occupational exposure to silica.
In this study, serum and urinary neopterin levels, both in silica-exposed workers ( n=22) and healthy volunteers ( n=20), were investigated by ELISA, spectrophotometry and HPLC techniques.
Serum neopterin levels of control and exposed groups were measured as 5.98+ or -0.44 and 7.86+ or -1.97 nmol/l, respectively ( P<0.05). Urinary neopterin levels were also increased in the exposed group: 97.60+ or -41.42 micromol/mol creatinine for controls and 165.59+/-78.20 micromol/mol creatinine for workers ( P<0.05). At the same time, the correlation between urinary neopterin levels, serum neopterin concentration and working years, smoking status, some complaints, and silica status in the working atmosphere were evaluated.
Our findings suggest that the following up of neopterin levels may have diagnostic value in silica-related diseases such as silicosis. Moreover, its biological monitoring should be performed in workplaces for clinical diagnosis and prognosis.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>12768284</pmid><doi>10.1007/s00420-003-0434-9</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Air Pollutants, Occupational - adverse effects Biological and medical sciences Biomarkers Biomarkers - blood Biomarkers - urine Biomonitoring Chemical and industrial products toxicology. Toxic occupational diseases Chronic obstructive pulmonary disease Contaminants Humans Immune system Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.) Liquid chromatography Lung cancer Lung Diseases - chemically induced Lung Diseases - diagnosis Male Medical sciences Neopterin - blood Neopterin - urine Occupational Diseases - chemically induced Occupational Diseases - diagnosis Occupational exposure Occupational hazards Respiratory diseases Risk exposure Silica Silicon Dioxide - adverse effects Silicosis Spectrophotometry Toxicology |
| title | Neopterin as a new biomarker for the evaluation of occupational exposure to silica |
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