Optimization of a Modified QuEChERS Method for Multiresidue Analysis of Pharmaceuticals and Personal Care Products in Sewage and Surface Water by LC-MS/MS

A quick, sensitive multiresidue method was developed for the analysis of 19 multiclass pharmaceuticals and personal care products (PPCPs) in surface water and sewage water. The proposed modified QuEChERS method involved the extraction of water samples (10 mL) with acetonitrile (10 mL) after the addi...

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Bibliographic Details
Published in:Journal of AOAC International 2017-05, Vol.100 (3), p.592-597
Main Authors: Kachhawaha, Akanksha S, Nagarnaik, Pranav M, Jadhav, Manjusha, Pudale, Anjali, Labhasetwar, Pawan K, Banerjee, Kaushik
Format: Article
Language:English
Subjects:
Chemical properties
Chromatography, Liquid
Cosmetics - analysis
Drug Residues - analysis
Drugs
Methods
Optimization theory
Personal care products
Sewage
Sewage - analysis
Surface water
Tandem Mass Spectrometry
Water - analysis
Water Pollutants, Chemical - analysis
Water quality bioassay
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Summary:A quick, sensitive multiresidue method was developed for the analysis of 19 multiclass pharmaceuticals and personal care products (PPCPs) in surface water and sewage water. The proposed modified QuEChERS method involved the extraction of water samples (10 mL) with acetonitrile (10 mL) after the addition of 1% acetic acid, 4 g magnesium sulfate, and 0.2 g ammonium acetate, and was validated in distilled water, surface water, and sewage water with respect to linearity, LOD and LOQ, precision, and accuracy. The LOD and LOQ varied within the ranges of 0.001-0.167 and 0.002-0.25 ng/mL, respectively. Recoveries of the target compounds ranged from 73 to 125%, with precision RSD values
ISSN:1060-3271
1944-7922
DOI:10.5740/jaoacint.17-0060