Absence of Correlation Between Vancomycin Consumption and Minimum Inhibitory Concentration of Methicillin-Resistant Staphylococcus aureus Isolates

There is limited evidence of a correlation between MRSA active antimicrobial agent consumption and the emergence of resistance.5 In this study, we aimed to assess the existence of vancomycin MIC creep among MRSA isolates obtained from blood cultures and to determine whether a correlation exists betw...

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Bibliographic Details
Published in:Infection control and hospital epidemiology 2017-06, Vol.38 (6), p.751-753
Main Authors: Riche, Cezar Vinícius Würdig, da Silva, Renato Cassol Ferreira, Ferreira, Jorge Alberto Santiago, Dias, Cícero Armídio Gomes, Falci, Diego Rodrigues
Format: Article
Language:English
Subjects:
Antibiotics
Antimicrobial agents
Laboratories
Mortality
Nursing
Staphylococcus infections
Variance analysis
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Summary:There is limited evidence of a correlation between MRSA active antimicrobial agent consumption and the emergence of resistance.5 In this study, we aimed to assess the existence of vancomycin MIC creep among MRSA isolates obtained from blood cultures and to determine whether a correlation exists between vancomycin consumption and variations in the MIC over time. [...]when the Etest period was considered separately, the same phenomenon was detected. The correlation between consumption and antimicrobial resistance is difficult to demonstrate in studies that do not involve a large number of isolates or a prolonged period of evaluation.5,9 The MIC creep phenomenon may not be associated with the emergence of de novo resistance caused by antimicrobial consumption, but it may be associated with clonal selection and the spread of isolates with higher vancomycin MICs.6,10 This study has some limitations, such as not evaluating the consumption of other anti-MRSA drugs.
ISSN:0899-823X
1559-6834
DOI:10.1017/ice.2017.39