Prevalence of microcephaly in eight south-eastern and midwestern Brazilian neonatal intensive care units: 2011–2015

ObjectiveTo describe the prevalence of microcephaly in infants admitted to the neonatal intensive care units (NICUs) in eight private hospitals in south-eastern and midwestern Brazil, from 2011 to 2015.DesignObservational, cross-sectional study in a cohort of neonates.SettingEight private NICUs situ...

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Bibliographic Details
Published in:Archives of disease in childhood 2017-08, Vol.102 (8), p.728-734
Main Authors: de Magalhães-Barbosa, Maria Clara, Prata-Barbosa, Arnaldo, Robaina, Jaqueline Rodrigues, Raymundo, Carlos Eduardo, Lima-Setta, Fernanda, Antonio José Ledo Alves da Cunha
Format: Article
Language:English
Subjects:
Age
Anatomy
Annual variations
Birth defects
Body Weight
Brazil - epidemiology
Congenital diseases
Cross-Sectional Studies
Epidemics
Female
Gestational Age
Health surveillance
Hospitals
Humans
Infant, Newborn
Infants
Infections
Intensive care
Intensive care units
Intensive Care Units, Neonatal
Male
Microcephaly
Microcephaly - epidemiology
Microencephaly
Neonatal intensive care units
Neonates
Nervous system
Neurological disorders
Newborn babies
Outbreaks
Pregnancy
Premature Birth - epidemiology
Premature Infants
Prevalence
Risk factors
Services
Term Birth - physiology
Vector-borne diseases
Young Children
Zika virus
Zika Virus Infection - epidemiology
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Summary:ObjectiveTo describe the prevalence of microcephaly in infants admitted to the neonatal intensive care units (NICUs) in eight private hospitals in south-eastern and midwestern Brazil, from 2011 to 2015.DesignObservational, cross-sectional study in a cohort of neonates.SettingEight private NICUs situated in the cities of Rio de Janeiro (RJ), São Paulo (SP) and Federal District of Brasilia (FDB).PatientsNeonates up to 7 days of age and >23 weeks of gestational age.Main outcome measuresPrimary outcomes were the annual prevalence of microcephaly and severe microcephaly, both overall and in subgroups according to gestational age, type of microcephaly (proportional or disproportional) and the NICU's location in RJ, SP or FDB.ResultsIn this cohort of 8275 neonates admitted to eight private NICUs, the overall prevalence of microcephaly was 5.6% (95% CI 5.1% to 6.1%) and severe microcephaly, 1.5% (95% CI 1.2% to 1.7%). There was no annual variation in these overall estimates (p=0.48 and p=0.99, respectively), nor in the studied subgroups. Microcephaly prevalence was higher in extremely premature and term newborns (7.7% and 7.2%; p
ISSN:0003-9888
1468-2044
DOI:10.1136/archdischild-2016-311541