Assessment of Nutritional and Inflammatory Status to Determine the Prevalence of Malnutrition in Patients Undergoing Surgery for Colorectal Carcinoma

Colorectal Cancer is the fourth most frequent cause of cancer death worldwide and its incidence increases from 50 years of age. It is often associated with protein-caloric malnutrition and 20% of cancer deaths occur due to this event. The aim of this study was to assess the prevalence of malnutritio...

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Bibliographic Details
Published in:Anticancer research 2017-03, Vol.37 (3), p.1281-1288
Main Authors: Daniele, Antonella, Divella, Rosa, Abbate, Ines, Casamassima, Addolorata, Garrisi, Vito Michele, Savino, Eufemia, Casamassima, Porzia, Ruggieri, Eustachio, DE Luca, Raffaele
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Appetite
C-Reactive Protein - metabolism
Case-Control Studies
Colorectal Neoplasms - complications
Colorectal Neoplasms - physiopathology
Colorectal Neoplasms - surgery
Cross-Sectional Studies
Diet
Female
Humans
Inflammation - complications
Inflammation - diagnosis
Interleukin-6 - metabolism
Male
Malnutrition - complications
Malnutrition - diagnosis
Middle Aged
Nutrition Assessment
Nutritional Status
Prevalence
Quality of Life
Transferrin - metabolism
Tumor Necrosis Factor-alpha - metabolism
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Summary:Colorectal Cancer is the fourth most frequent cause of cancer death worldwide and its incidence increases from 50 years of age. It is often associated with protein-caloric malnutrition and 20% of cancer deaths occur due to this event. The aim of this study was to assess the prevalence of malnutrition and inflammatory status in 78 patients undergoing surgery for colorectal carcinoma. Nutritional Status was assessed by Mini Nutritional Assessment (MNA). Serum levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were measured by ELISA, while albumin, C-reactive protein (CRP) and transferrin (TRF) were tested using an immunometric assay. The mean MNA score in colorectal patients was 20.4±8.4, while 23/78 patients (29.4%) were well nourished, 36/78 (46.1%) were at risk of malnutrition and 19/78 (24.3%) were malnourished, reporting in the previous six months from the date of diagnosis a significant weight loss (>10 kg), muscle mass loss and severe reduction of food intake due to loss of appetite and altered taste perception. The serum means of IL-6, TNF-α and CRP, were significantly higher in colorectal patients compared to the control group (p
ISSN:0250-7005
1791-7530
DOI:10.21873/anticanres.11445