Relationship between asymmetric dimethylarginine in umbilical cord plasma and birth weight follows a U-shaped curve

Asymmetric dimethylarginine (ADMA) is a nonselective nitric oxide (NO) synthase inhibitor associated with cardiovascular and metabolic disorders. NO regulates placental blood flow, which plays an important role in fetal growth. Many epidemiological studies have disclosed that restricted fetal growth...

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Bibliographic Details
Published in:ENDOCRINE JOURNAL 2017, Vol.64(4), pp.431-436
Main Authors: Takaya, Junji, Tanabe, Yuko, Kuroyanagi, Yuichi, Kaneko, Kazunari
Format: Article
Language:English
Subjects:
Adiponectin
Appropriate for gestational age
Arginine - analogs & derivatives
Arginine - blood
Arginine - metabolism
Asymmetric dimethylarginine
Birth weight
Birth Weight - physiology
Blood flow
Child Development - physiology
Computer Graphics
Cord blood
Epidemiology
Female
Fetal Blood - chemistry
Fetal Blood - metabolism
Fetuses
Gestational Age
Growth Charts
Humans
Infant, Newborn
Infant, Small for Gestational Age - blood
Infants
Insulin
Insulin - blood
Insulin resistance
Insulin-like growth factor I
Insulin-Like Growth Factor I - metabolism
Insulin-like growth factors
Leptin
Leptin - blood
Male
Metabolic disorders
Nitric oxide
Oxides
Placenta
Prenatal development
Quantitative insulin sensitivity check index
Small for gestational age
Umbilical cord
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Summary:Asymmetric dimethylarginine (ADMA) is a nonselective nitric oxide (NO) synthase inhibitor associated with cardiovascular and metabolic disorders. NO regulates placental blood flow, which plays an important role in fetal growth. Many epidemiological studies have disclosed that restricted fetal growth is associated with an increased risk of insulin resistance in adult life. We studied the relationship between ADMA in cord blood and birth size. Nine small for gestational age (SGA) and 32 appropriate for gestational age (AGA) infants were studied. Their cord plasma ADMA, insulin, insulin-like growth factor-1 (IGF-1), and adipocytokine levels were determined using enzyme-linked immunosorbent assays. The relationship between birth weight and ADMA levels followed a U-shaped curve rather than inverse linear associations expected over a full range of birth weight distribution. ADMA positively correlated with birth weight in the AGA group (p
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.EJ16-0378