Does percutaneous coronary stent implantation increase platelet reactivity?

Abstract High platelet reactivity (PR) values on treatment with clopidogrel are associated with an increased rate of thrombotic events after a percutaneous coronary intervention (PCI). However, we do not know the optimal timing of the performance of the PR measurements. Platelets might be activated...

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Bibliographic Details
Published in:Blood reviews 2017-09, Vol.31 (5), p.271-275
Main Authors: Janssen, P.W.A, Mol, E.A, Geene, S.M.C, Barbato, E, ten Berg, J.M
Format: Article
Language:English
Subjects:
Blood Platelets - drug effects
Blood Platelets - physiology
Clopidogrel
Coronary Disease - blood
Coronary Disease - diagnosis
Coronary Disease - therapy
Hematology, Oncology and Palliative Medicine
Humans
Percutaneous coronary intervention
Percutaneous Coronary Intervention - adverse effects
Percutaneous Coronary Intervention - methods
Platelet Activation
Platelet Aggregation Inhibitors - pharmacology
Platelet Function Tests
Platelet reactivity
Stenting
Stents - adverse effects
Ticlopidine - analogs & derivatives
Ticlopidine - pharmacology
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Summary:Abstract High platelet reactivity (PR) values on treatment with clopidogrel are associated with an increased rate of thrombotic events after a percutaneous coronary intervention (PCI). However, we do not know the optimal timing of the performance of the PR measurements. Platelets might be activated during a PCI, which means that the timing of PR measurements, before or after PCI, could influence the outcome. In turn, this could lead to misinterpretation of the patient's response to antiplatelet therapy and a less accurate prediction of the patient's risk of thrombotic events during follow-up. We aimed to evaluate the effect of stent implantation on PR in patients with and without acute coronary syndromes who undergo PCI to assess the optimal timing of PR measurements. A systematic literature search was performed and the results are summarized in this review.
ISSN:0268-960X
1532-1681
DOI:10.1016/j.blre.2017.03.003