Synthesis of Polysubstituted 3‑Amino Pyrroles via Palladium-Catalyzed Multicomponent Reaction

A novel approach for the synthesis of polysubstituted 3-amino pyrroles via palladium-catalyzed three-component tandem reaction was developed. The procedure constructs various polysubstituted 3-amino pyrroles with moderate to excellent yields under mild reaction conditions with assembly efficiency, r...

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Bibliographic Details
Published in:Journal of organic chemistry 2017-04, Vol.82 (7), p.3581-3588
Main Authors: Peng, Jianwen, Gao, Yang, Zhu, Chuanle, Liu, Bifu, Gao, Yinglan, Hu, Miao, Wu, Wanqing, Jiang, Huanfeng
Format: Article
Language:English
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Summary:A novel approach for the synthesis of polysubstituted 3-amino pyrroles via palladium-catalyzed three-component tandem reaction was developed. The procedure constructs various polysubstituted 3-amino pyrroles with moderate to excellent yields under mild reaction conditions with assembly efficiency, readily available starting materials, and good functional group tolerance. Furthermore, this process was successfully applied to the synthesis of different 3-phenyl-1,4-dihydropyrrolo­[3,2-b]­indole derivatives via an intramolecular Buchwald–Hartwig cross-coupling reaction in two steps.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.7b00098