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Classification and characterization of periventricular and deep white matter hyperintensities on MRI: A study in older adults

White matter hyperintensities (WMH) are frequently divided into periventricular (PWMH) and deep (DWMH), and the two classes have been associated with different cognitive, microstructural, and clinical correlates. However, although this distinction is widely used in visual ratings scales, how to best...

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Published in:NeuroImage (Orlando, Fla.) Fla.), 2018-04, Vol.170, p.174-181
Main Authors: Griffanti, Ludovica, Jenkinson, Mark, Suri, Sana, Zsoldos, Enikő, Mahmood, Abda, Filippini, Nicola, Sexton, Claire E, Topiwala, Anya, Allan, Charlotte, Kivimäki, Mika, Singh-Manoux, Archana, Ebmeier, Klaus P., Mackay, Clare E., Zamboni, Giovanna
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container_title NeuroImage (Orlando, Fla.)
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creator Griffanti, Ludovica
Jenkinson, Mark
Suri, Sana
Zsoldos, Enikő
Mahmood, Abda
Filippini, Nicola
Sexton, Claire E
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Allan, Charlotte
Kivimäki, Mika
Singh-Manoux, Archana
Ebmeier, Klaus P.
Mackay, Clare E.
Zamboni, Giovanna
description White matter hyperintensities (WMH) are frequently divided into periventricular (PWMH) and deep (DWMH), and the two classes have been associated with different cognitive, microstructural, and clinical correlates. However, although this distinction is widely used in visual ratings scales, how to best anatomically define the two classes is still disputed. In fact, the methods used to define PWMH and DWMH vary significantly between studies, making results difficult to compare. The purpose of this study was twofold: first, to compare four current criteria used to define PWMH and DWMH in a cohort of healthy older adults (mean age: 69.58 ± 5.33 years) by quantifying possible differences in terms of estimated volumes; second, to explore associations between the two WMH sub-classes with cognition, tissue microstructure and cardiovascular risk factors, analysing the impact of different criteria on the specific associations. Our results suggest that the classification criterion used for the definition of PWMH and DWMH should not be considered a major obstacle for the comparison of different studies. We observed that higher PWMH load is associated with reduced cognitive function, higher mean arterial pressure and age. Higher DWMH load is associated with higher body mass index. PWMH have lower fractional anisotropy than DWMH, which also have more heterogeneous microstructure. These findings support the hypothesis that PWMH and DWMH are different entities and that their distinction can provide useful information about healthy and pathological aging processes. •Classification criteria for periventricular/deep white matter hyperintensities are compared.•The definition of PWMH and DWMH is not a major obstacle for study comparison.•PWMH and DWMH have different functional, microstructural and clinical correlates.•10mm distance rule gave best separation in terms of associations with the tested factors.
doi_str_mv 10.1016/j.neuroimage.2017.03.024
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identifier ISSN: 1053-8119
ispartof NeuroImage (Orlando, Fla.), 2018-04, Vol.170, p.174-181
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source ScienceDirect Freedom Collection 2022-2024
subjects Age
Age Factors
Aged
Aging
Aging - pathology
Blood pressure
Body Mass Index
Brain research
Cardiovascular diseases
Classification
Cognitive ability
Cognitive Dysfunction - diagnostic imaging
Cognitive Dysfunction - pathology
Cohort Studies
Female
Humans
Hypertension - diagnostic imaging
Hypertension - pathology
Leukoaraiosis - classification
Leukoaraiosis - diagnostic imaging
Leukoaraiosis - pathology
Magnetic resonance imaging
Male
Medical imaging
Middle Aged
Neuroimaging - methods
NMR
Nuclear magnetic resonance
Older people
Psychiatry
Risk factors
Studies
Substantia alba
title Classification and characterization of periventricular and deep white matter hyperintensities on MRI: A study in older adults
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