The bridging integrator 1 Gene rs7561528 polymorphism contributes to Alzheimer's disease susceptibility in East Asian and Caucasian populations

Genetic variants of the bridging integrator 1 (BIN1) at the rs7561528 single nucleotide polymorphism were implicated in increased risk of Alzheimer's disease in several case-control association studies. However, the studies have reported apparently conflicting results. Here, we searched the Pub...

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Bibliographic Details
Published in:Clinica chimica acta 2017-06, Vol.469, p.13-21
Main Authors: Zhou, Futao, Haina, Dong
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing - genetics
Alzheimer Disease - genetics
Alzheimer's disease
Asian Continental Ancestry Group - genetics
Association
Bridging integrator 1
European Continental Ancestry Group - genetics
Far East
Genetic Predisposition to Disease - genetics
Humans
Meta-analysis
Nuclear Proteins - genetics
Polymorphism
Polymorphism, Single Nucleotide
Tumor Suppressor Proteins - genetics
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Summary:Genetic variants of the bridging integrator 1 (BIN1) at the rs7561528 single nucleotide polymorphism were implicated in increased risk of Alzheimer's disease in several case-control association studies. However, the studies have reported apparently conflicting results. Here, we searched the PubMed and Google Scholar databases. In total, 17,179 AD patients and 17,448 healthy controls (HCs) from 18 studies are included in the current study to examine the association between this polymorphism and AD risk. Significant associations of the SNP rs242557 with AD are found under allelic [A vs. G: odds ratio (OR)=0.86, 95% confidence interval (CI)=0.78, 0.96, P=0.006], dominant (AA+AG vs. GG: OR=0.87, 95% CI=0.77, 0.97, P=0.01), recessive (AA vs. AG+GG: OR=0.86, 95% CI=0.76, 0.98, P=0.21), homozygous (AA vs. GG: OR=0.86, 95% CI=0.76, 0.99, P=0.03) and heterozygous (AG vs. GG: OR=0.87, 95% CI=0.83, 0.92, P
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2017.03.013