The levonorgestrel-releasing intrauterine device potentiates stress reactivity

Highlights • LNG-IUD is associated with a robust potentiation of HPA axis responsivity. • LNG-IUD potentiates the autonomic heart rate response during psychosocial stress. • The mechanism of LNG-IUD sensitization of the HPA axis is centrally-mediated

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Bibliographic Details
Published in:Psychoneuroendocrinology 2017-06, Vol.80, p.39-45
Main Authors: Aleknaviciute, Jurate, Tulen, Joke H.M, De Rijke, Yolanda B, Bouwkamp, Christian G, van der Kroeg, Mark, Timmermans, Mirjam, Wester, Vincent L, Bergink, Veerle, Hoogendijk, Witte J.G, Tiemeier, Henning, van Rossum, Elisabeth F.C, Kooiman, Cornelis G, Kushner, Steven A
Format: Article
Language:English
Subjects:
Adrenocorticotropic hormone
Adrenocorticotropic Hormone - metabolism
Adult
Affective disorders
Autonomic nervous system
Contraceptive Agents, Female - pharmacology
Cortisol
Cross-Sectional Studies
Endocrinology & Metabolism
Ethinyl Estradiol
Female
Humans
Hydrocortisone - analysis
Hydrocortisone - blood
Hypothalamo-Hypophyseal System - drug effects
Hypothalamus-Pituitary-Adrenal (HPA) axis
Intrauterine Devices
Levonorgestrel - metabolism
Levonorgestrel - pharmacology
Levonorgestrel-releasing intrauterine device
Long-acting reversible contraception (LARC)
Pituitary-Adrenal System - drug effects
Psychiatry
Saliva
Young Adult
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Description
Summary:Highlights • LNG-IUD is associated with a robust potentiation of HPA axis responsivity. • LNG-IUD potentiates the autonomic heart rate response during psychosocial stress. • The mechanism of LNG-IUD sensitization of the HPA axis is centrally-mediated
ISSN:0306-4530
1873-3360
DOI:10.1016/j.psyneuen.2017.02.025