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The levonorgestrel-releasing intrauterine device potentiates stress reactivity

Highlights • LNG-IUD is associated with a robust potentiation of HPA axis responsivity. • LNG-IUD potentiates the autonomic heart rate response during psychosocial stress. • The mechanism of LNG-IUD sensitization of the HPA axis is centrally-mediated

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Published in:Psychoneuroendocrinology 2017-06, Vol.80, p.39-45
Main Authors: Aleknaviciute, Jurate, Tulen, Joke H.M, De Rijke, Yolanda B, Bouwkamp, Christian G, van der Kroeg, Mark, Timmermans, Mirjam, Wester, Vincent L, Bergink, Veerle, Hoogendijk, Witte J.G, Tiemeier, Henning, van Rossum, Elisabeth F.C, Kooiman, Cornelis G, Kushner, Steven A
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container_title Psychoneuroendocrinology
container_volume 80
creator Aleknaviciute, Jurate
Tulen, Joke H.M
De Rijke, Yolanda B
Bouwkamp, Christian G
van der Kroeg, Mark
Timmermans, Mirjam
Wester, Vincent L
Bergink, Veerle
Hoogendijk, Witte J.G
Tiemeier, Henning
van Rossum, Elisabeth F.C
Kooiman, Cornelis G
Kushner, Steven A
description Highlights • LNG-IUD is associated with a robust potentiation of HPA axis responsivity. • LNG-IUD potentiates the autonomic heart rate response during psychosocial stress. • The mechanism of LNG-IUD sensitization of the HPA axis is centrally-mediated
doi_str_mv 10.1016/j.psyneuen.2017.02.025
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source ScienceDirect Journals
subjects Adrenocorticotropic hormone
Adrenocorticotropic Hormone - metabolism
Adult
Affective disorders
Autonomic nervous system
Contraceptive Agents, Female - pharmacology
Cortisol
Cross-Sectional Studies
Endocrinology & Metabolism
Ethinyl Estradiol
Female
Humans
Hydrocortisone - analysis
Hydrocortisone - blood
Hypothalamo-Hypophyseal System - drug effects
Hypothalamus-Pituitary-Adrenal (HPA) axis
Intrauterine Devices
Levonorgestrel - metabolism
Levonorgestrel - pharmacology
Levonorgestrel-releasing intrauterine device
Long-acting reversible contraception (LARC)
Pituitary-Adrenal System - drug effects
Psychiatry
Saliva
Young Adult
title The levonorgestrel-releasing intrauterine device potentiates stress reactivity
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