Chronic Stress and Age-Related Increases in the Proinflammatory Cytokine IL-6

• Published in: Proceedings of the National Academy of Sciences - PNAS 2003-07, Vol.100 (15), p.9090-9095
• Main Authors: Kiecolt-Glaser, Janice K., Preacher, Kristopher J., MacCallum, Robert C., Atkinson, Cathie, Malarkey, William B., Glaser, Ronald
• Format: Article
• Language: English
• Subjects: Age; Aged; Aged, 80 and over; Aging - immunology; Body mass index; Caregivers; Caregivers - psychology; Case-Control Studies; Cells; Chronic Disease; Cytokines; Depressive disorders; Disease risk; Ethnicity; Female; Humans; Inflammation Mediators - blood; Interleukin-6 - blood; Linear Models; Loneliness; Male; Middle Aged; Models, Immunological; Multilevel models; Older adults; Psychology; Social Sciences; Spouses; Stress; Stress, Psychological - immunology
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.1531903100

Overproduction of IL-6, a proinflammatory cytokine, is associated with a spectrum of age-related conditions including cardiovascular disease, osteoporosis, arthritis, type 2 diabetes, certain cancers, periodontal disease, frailty, and functional decline. To describe the pattern of change in IL-6 over 6 years among older adults undergoing a chronic stressor, this longitudinal community study assessed the relationship between chronic stress and IL-6 production in 119 men and women who were caregiving for a spouse with dementia and 106 noncaregivers, with a mean age at study entry of 70.58 (SD = 8.03) for the full sample. On entry into this portion of the longitudinal study, 28 of the caregivers' spouses had already died, and an additional 50 of the 119 spouses died during the 6 years of this study. Levels of IL-6 and health behaviors associated with IL-6 were measured across 6 years. Caregivers' average rate of increase in IL-6 was about four times as large as that of noncaregivers. Moreover, the mean annual changes in IL-6 among former caregivers did not differ from that of current caregivers even several years after the death of the impaired spouse. There were no systematic group differences in chronic health problems, medications, or health-relevant behaviors that might have accounted for caregivers' steeper IL-6 slope. These data provide evidence of a key mechanism through which chronic stressors may accelerate risk of a host of age-related diseases by prematurely aging the immune response.