Hemodynamic improvement and removal of autoantibodies against β 1-adrenergic receptor by immunoadsorption therapy in dilated cardiomyopathy

The removal of β 1-adrenergic receptor (β 1AR) autoantibodies by immunoadsorption (IA) has been proposed as a potential mechanism for the improvement of the left ventricular function in dilated cardiomyopathy (DCM). In the present study, the possible association between removal of the autoantibodies...

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Bibliographic Details
Published in:Journal of autoimmunity 2003-06, Vol.20 (4), p.345-350
Main Authors: Mobini, Reza, Staudt, Alexander, Felix, Stephan B., Baumann, Gert, Wallukat, Gert, Deinum, Johanna, Svensson, Helen, Hjalmarson, Åke, Fu, Michael
Format: Article
Language:English
Subjects:
Autoantibodies
Immunoadsorption
β 1-Adrenergic receptor
Online Access:Get full text
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Summary:The removal of β 1-adrenergic receptor (β 1AR) autoantibodies by immunoadsorption (IA) has been proposed as a potential mechanism for the improvement of the left ventricular function in dilated cardiomyopathy (DCM). In the present study, the possible association between removal of the autoantibodies against the human β 1AR with the hemodynamic improvement induced by IA was investigated. IA was performed in 22 DCM patients ( n=22; NYHA III–IV, EF
ISSN:0896-8411
1095-9157
DOI:10.1016/S0896-8411(03)00042-8