Enzymuria following amphotericin B application in the rat

Summary The effect of amphotericin B application on urinary renal tubule enzyme excretion was investigated in rats treated with amphotericin B (1.5 mg kg−1 b.i.d., i.v.) for 4 days. Application of amphotericin B induced a significant higher daily urinary enzyme activity of the renal tubular enzymes...

Full description

Saved in:
Bibliographic Details
Published in:Mycoses 2003-06, Vol.46 (5-6), p.169-173
Main Authors: Inselmann, Gerhard, Balaschke, Michael, Heidemann, Hugo T.
Format: Article
Language:English
Subjects:
Acetylglucosaminidase - urine
Amphotericin B
Amphotericin B - administration & dosage
Amphotericin B - toxicity
Animals
Antifungal Agents - administration & dosage
Antifungal Agents - toxicity
CD13 Antigens - urine
creatinine clearance
gamma-Glutamyltransferase - urine
Glucuronidase - urine
Injections, Intravenous
Kidney Tubules - drug effects
Kidney Tubules - physiology
Kreatinin-Clearance
Male
nephrotoxicity
Nephrotoxizität
Nierentubuli-Enzyme
Rats
Rats, Sprague-Dawley
renal tubular enzymes
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary The effect of amphotericin B application on urinary renal tubule enzyme excretion was investigated in rats treated with amphotericin B (1.5 mg kg−1 b.i.d., i.v.) for 4 days. Application of amphotericin B induced a significant higher daily urinary enzyme activity of the renal tubular enzymes N‐acetyl‐β‐glucosaminidase (NAG), β‐glucuronidase (GRS), alanine‐aminopeptidase (AAP) and γ‐glutamyltransferase (GGT) in comparison with controls and sodium deoxycholate treated animals as well. A significant increase in the renal excretion of NAG, GRS, AAP and GGT occurred after the first day of amphotericin B treatment and continued until the fourth day. Following treatment for 4 days with amphotericin B urine AAP activity amounted to 69 ± 19 U g−1 creatinine, control: 39 ± 7 U g−1 creatinine (P 
ISSN:0933-7407
1439-0507
DOI:10.1046/j.1439-0507.2003.00856.x