Frontispiece: The Cysteine S‐Alkylation Reaction as a Synthetic Method to Covalently Modify Peptide Sequences

Solid‐ and Solution‐Phase Synthesis Modification of amino acid side chains in order to introduce chemical and functional diversities is a powerful tool for preparing peptidomimetics. This approach allows effective improvement of the bioavailability and resistance to metabolic breakdown of peptide mo...

Full description

Saved in:
Bibliographic Details
Published in:Chemistry : a European journal 2017-01, Vol.23 (2), p.np-n/a
Main Authors: Calce, Enrica, De Luca, Stefania
Format: Article
Language:English
Subjects:
Amino acids
Bioavailability
Breakdown
Chemistry
Covalence
Cysteine
cysteine thio-alkylation
Peptides
solid-phase synthesis
solution-phase synthesis
Synthesis (chemistry)
unnatural amino acids
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Solid‐ and Solution‐Phase Synthesis Modification of amino acid side chains in order to introduce chemical and functional diversities is a powerful tool for preparing peptidomimetics. This approach allows effective improvement of the bioavailability and resistance to metabolic breakdown of peptide molecules with therapeutic potential. For more information, see the Minireview by S. De Luca and E. Calce on page 224 ff.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201780261