MicroRNA-1284 inhibits proliferation and induces apoptosis in SGC-7901 human gastric cancer cells

Objectives To explore the functional effects of miR-1284 on gastric cancer cells. Results Overexpression of miR-1284 significantly reduced SGC-7901 cell proliferation, but improved apoptosis. However, miR-1284 suppression displayed the inversed impacts. Furthermore, the protein levels of p27, Bax, p...

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Published in:Biotechnology letters 2017, Vol.39 (1), p.33-38
Main Authors: Huang, Mingwei, Wu, Liucheng, Luo, Shanshan, Qin, Haiquan, Yang, Yang, Chen, Jiansi, Li, Zhao, Qin, Yuzhou
Format: Article
Language:English
Subjects:
Apoptosis
Apoptosis - genetics
Apoptosis - physiology
Applied Microbiology
Biochemistry
Biomedical and Life Sciences
Biotechnology
Cancer
Caspase 3 - metabolism
Cell growth
Cell Line, Tumor
Cell Proliferation - genetics
Cell Proliferation - physiology
Chromium
Gastric cancer
Gene Expression Regulation, Neoplastic - genetics
Gene Expression Regulation, Neoplastic - physiology
Humans
Life Sciences
Microbiology
MicroRNAs
MicroRNAs - genetics
MicroRNAs - physiology
Original Research Paper
Proteins
Stomach Neoplasms - genetics
Stomach Neoplasms - metabolism
Suppressors
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Summary:Objectives To explore the functional effects of miR-1284 on gastric cancer cells. Results Overexpression of miR-1284 significantly reduced SGC-7901 cell proliferation, but improved apoptosis. However, miR-1284 suppression displayed the inversed impacts. Furthermore, the protein levels of p27, Bax, procaspase-3 and active caspase-3 were up-regulated by miR-1284 overexpression, but were down-regulated by miR-1284 suppression. The level of Bcl-2 was down-regulated by miR-1284 overexpression, while it was up-regulated by miR-1284 suppression. The level of p21 was unaffected. Conclusion These results suggest that miR-1284 overexpression might be a suppressor for gastric cancer via controlling of cell proliferation and apoptosis.
ISSN:0141-5492
1573-6776
DOI:10.1007/s10529-016-2213-1