Esterase-Activated Charge-Reversal Polymer for Fibroblast-Exempt Cancer Gene Therapy

Selective gene expression in tumors via responsive dissociation of polyplexes triggered by intracellular signals is demonstrated. An esterase‐responsive charge‐reversal polymer mediates selective gene expression in the cancer cells high in esterases over fibroblasts low in esterase activity. Its gen...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2016-12, Vol.28 (48), p.10613-10622
Main Authors: Qiu, Nasha, Liu, Xiangrui, Zhong, Yin, Zhou, Zhuxian, Piao, Ying, Miao, Lei, Zhang, Qianzhi, Tang, Jianbin, Huang, Leaf, Shen, Youqing
Format: Article
Language:English
Subjects:
Apoptosis
Apoptosis - genetics
Cancer
cancer gene therapy
Charge reversal
charge-reversal polymer
esterase-responsive
Esterases
Esterases - metabolism
fibroblast exempt
Fibroblasts
Fibroblasts - enzymology
Fibroblasts - metabolism
Gene expression
Gene Expression Regulation, Neoplastic
Gene therapy
Genes
Genes, Transgenic, Suicide - genetics
Genetic Therapy
HeLa Cells
Humans
intraperitoneal tumors
Materials science
Neoplasms - enzymology
Neoplasms - genetics
Neoplasms - therapy
Polymers - chemistry
Side effects
Tumors
Wnt Proteins - metabolism
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Summary:Selective gene expression in tumors via responsive dissociation of polyplexes triggered by intracellular signals is demonstrated. An esterase‐responsive charge‐reversal polymer mediates selective gene expression in the cancer cells high in esterases over fibroblasts low in esterase activity. Its gene therapy with the TRAIL suicide gene effectively induces apoptosis of HeLa cells but does not activate fibroblasts to secrete WNT16B, enabling potent cancer gene therapy with few side effects.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201603095