Mitochondria-targeted theranostic nanoparticles for optical sensing of oxygen, photodynamic cancer therapy, and assessment of therapeutic efficacy

We report on a novel kind of mitochondria-targeted theranostic nanoparticles (NPs). The NPs are doped with the oxygen-sensitive probe Pt(II)-porphyrins (PtTFPP) which exerts a dual role in acting as a diagnostic tool that can sense oxygen via quenching of luminescence, but also acts as an agent in p...

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Bibliographic Details
Published in:Mikrochimica acta (1966) 2016-10, Vol.183 (10), p.2723-2731
Main Authors: Wang, Xiao-Hui, Peng, Hong-Shang, Yang, Wei, Ren, Zhao-Di, Liu, Yuan-An
Format: Article
Language:English
Subjects:
Analytical Chemistry
Assessments
Cancer
Care and treatment
Cell death
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Diagnostic software
Diagnostic systems
Effectiveness
Energy transfer
Health aspects
Light irradiation
Luminescence
Microengineering
Mitochondria
Nanochemistry
Nanoparticles
Nanotechnology
Original Paper
Oxygen
Oxygen consumption
Photochemotherapy
Photodynamic therapy
Porphyrins
Quenching
Reagents
Singlet oxygen
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Summary:We report on a novel kind of mitochondria-targeted theranostic nanoparticles (NPs). The NPs are doped with the oxygen-sensitive probe Pt(II)-porphyrins (PtTFPP) which exerts a dual role in acting as a diagnostic tool that can sense oxygen via quenching of luminescence, but also acts as an agent in photodynamic therapy (PDT) of cancer. In addition, it allows therapeutic efficacy to be assessed in-situ. Upon appropriate high-energy photoirradiation, the NPs generate singlet oxygen by energy transfer from triplet PtTFPP to ground state oxygen, and cell death is induced via PDT. Under low-energy light irradiation, in contrast, the NPs can be utilized to detect oxygen consumption rate via time-resolved luminescence measurements in order to study the efficacy of PDT. This is the first report where a single nanoagent is used to stimulate PDT and also to assess the efficacy of PDT. In our perception, the method provides a promising platform for testing anti-cancer drugs. Graphical abstract We report on a kind of mitochondria-targeted theranostic nanoparticles (NPs) doped with Pt(II)-porphyrins for oxygen sensing via quenching of luminescence, efficient photodynamic therapy (PDT) of cancer and quantitative assessment of therapeutic response in-situ.
ISSN:0026-3672
1436-5073
DOI:10.1007/s00604-016-1917-1