Copper(II)–Thymine Coordination Polymer Nanoribbons as Potential Oligonucleotide Nanocarriers

The direct reaction between copper nitrate, thymine‐1‐acetic acid, and 4,4′‐bipyridine in water leads to the formation of a blue colloid comprising uniform crystalline nanoribbons (length >1 μm; width ca. 150–185 nm; diameter ca. 15–60 nm) of a coordination polymer. The polymer displays a thymine...

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Published in:Angewandte Chemie 2017-01, Vol.129 (4), p.1007-1011
Main Authors: Vegas, Verónica G., Lorca, Romina, Latorre, Ana, Hassanein, Khaled, Gómez‐García, Carlos J., Castillo, Oscar, Somoza, Álvaro, Zamora, Félix, Amo‐Ochoa, Pilar
Format: Article
Language:English
Subjects:
Acetic acid
Adenine
Adenines
Cell lines
Chemistry
Coordination polymers
Copper
Copper compounds
Crystal structure
Displays
Koordinationspolymere
Nanobänder
Nanoribbons
Nanostructure
Nanotransporter
Nitrates
Oligonucleotides
Oligonukleotide
Polymers
Thymine
Toxicity
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Summary:The direct reaction between copper nitrate, thymine‐1‐acetic acid, and 4,4′‐bipyridine in water leads to the formation of a blue colloid comprising uniform crystalline nanoribbons (length >1 μm; width ca. 150–185 nm; diameter ca. 15–60 nm) of a coordination polymer. The polymer displays a thymine‐based structure freely available for supramolecular interactions. These nanostructures show significant selective interaction with single‐stranded oligonucleotides based on adenine. Remarkably, they present low cell toxicity in three cell lines–despite the copper(II) content–and can be used as nanocarriers of oligonucleotides. These results suggest the potential of these types of nanostructures in several biological applications. Kristalline Nanobänder eines Kupfer‐Thymin‐Koordinationspolymers binden bevorzugt an Adenin‐haltige Oligonukleotide und sind nur schwach zytotoxisch. Die Nanostrukturen eignen sich für den Transport von Oligonukleotiden in Zellen.
ISSN:0044-8249
1521-3757
DOI:10.1002/ange.201609031