Nano-plasmonic-based structures for DNA sequencing

We propose novel nano-plasmonic-based structures for rapid sequencing of DNA molecules. The optical properties of DNA nucleotides have notable differences in the ultraviolet (UV) region of light. Using nanopore, bowtie, and bowtie-nanopore compound structures, probable application of the surface pla...

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Bibliographic Details
Published in:Optics letters 2016-09, Vol.41 (18), p.4229-4232
Main Authors: Fotouhi, Bashir, Ahmadi, Vahid, Faramarzi, Vahid
Format: Article
Language:English
Subjects:
Aluminum
Base Sequence
Chromium
Deoxyribonucleic acid
DNA
Gene sequencing
Graphene
Graphite - chemistry
Molecular structure
Nanopores
Nanostructure
Nucleotides
Sequence Analysis, DNA
Surface Plasmon Resonance - methods
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Summary:We propose novel nano-plasmonic-based structures for rapid sequencing of DNA molecules. The optical properties of DNA nucleotides have notable differences in the ultraviolet (UV) region of light. Using nanopore, bowtie, and bowtie-nanopore compound structures, probable application of the surface plasmon resonance (SPR) in DNA sequencing is investigated by employing the discrete dipole approximation method. The effects of different materials like chromium (Cr), aluminum (Al), rhodium (Rh), and graphene (Gr) are studied. We show that for Cr/Al/Gr/Rh, the nucleotide presented shifts the SPR spectra for the nanopore 1/29/5/34 to 14/39/15/67 nm, bowtie 8/2/49/38 to 31/20/79/55 nm, and bowtie-nanopore compound 25/77/5/16 to 80/80/22/39 nm. The Cr-based compound structure shows excellent sensitivity and selectivity which can make it a promising methodology for DNA sequencing.
ISSN:0146-9592
1539-4794
DOI:10.1364/OL.41.004229