On‐line approaches for the determination of residues and contaminants in complex samples

The determination of residues and contaminants in complex matrices such as in the case of food, environmental, and biological samples requires a combination of several steps to succeed in the aimed goal. At least three independent steps are integrated to provide the best available situation to deal...

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Bibliographic Details
Published in:Journal of separation science 2017-01, Vol.40 (1), p.183-202
Main Authors: Fumes, Bruno Henrique, Andrade, Mariane Aissa, Franco, Maraíssa Silva, Lanças, Fernando Mauro
Format: Article
Language:English
Subjects:
Analyzers
Biological properties
Chemistry Techniques, Analytical - instrumentation
Chemistry Techniques, Analytical - standards
Chromatography
Contaminants
Coupling
Environmental Monitoring - instrumentation
Food Analysis - instrumentation
Food contamination & poisoning
Foods
Humans
In‐tube solid‐phase extraction
Microextraction techniques
Multidimensional separations
On‐line analysis
Qualitative analysis
Quantitative analysis
Residues
Turbulent flow
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Summary:The determination of residues and contaminants in complex matrices such as in the case of food, environmental, and biological samples requires a combination of several steps to succeed in the aimed goal. At least three independent steps are integrated to provide the best available situation to deal with such matrices: (1) a sample preparation technique is employed to isolate the target compounds from the rest of the matrix; (2) a chromatographic (second) step further “purifies” the isolated compounds from the co‐extracted matrix interferences; (3) a spectroscopy‐based device acts as chromatographic detector (ideally containing a tandem high‐resolution mass analyzer) for the qualitative and quantitative analysis. These techniques can be operated in different modes including the off‐line and the on‐line modes. The present report focus the on‐line coupling techniques aiming the determination of analytes present in complex matrices. The fundamentals of these approaches as well as the most common set ups are presented and discussed, as well as a review on the recent applications of these two approaches to the fields of bioanalytical, environmental, and food analysis are critically discussed.
ISSN:1615-9306
1615-9314
DOI:10.1002/jssc.201600867