Studying the Kinetics of n-Butyl-Cyanoacrylate Tissue Adhesive and Its Oily Mixtures

This study deals with the measurement of the kinetics of tissue adhesives used for supporting the hemostasis and wound closure during surgical intervention. There are available several types of adhesives of different composition which is closely related with their application. When selecting an appr...

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Bibliographic Details
Published in:Journal of infrared, millimeter and terahertz waves millimeter and terahertz waves, 2016-10, Vol.37 (10), p.1043-1054
Main Authors: Nedvedova, Marie, Kresalek, Vojtech, Vaskova, Hana, Provaznik, Ivo
Format: Article
Language:English
Subjects:
Adhesion tests
Adhesives
Blood vessels
Classical Electrodynamics
Closures
Composition
Curing
Cyanoacrylates
Electrical Engineering
Electronics and Microelectronics
Engineering
Glues
Hemostatics
Instrumentation
Kinetics
Microscopy
Mixtures
Optical microscopy
Polymerization
Raman spectroscopy
Reaction kinetics
Reflection
Solidification
Spectroscopic analysis
Spectrum analysis
Time measurement
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Summary:This study deals with the measurement of the kinetics of tissue adhesives used for supporting the hemostasis and wound closure during surgical intervention. There are available several types of adhesives of different composition which is closely related with their application. When selecting an appropriate adhesive, the time of curing could play an important role because some applications may require very fast polymerization for prompt vessel or wound closure; conversely, some situations need slower solidification because of longer manipulation with the glue during surgery. The terahertz time-domain spectroscopy is used for studying the kinetics of the n-butyl-cyanoacrylate glue in this study. An oily substance is added to the glue samples to slow the reaction rate. The technique of attenuated total reflection is used in this application; the defined amount of glue sample or its mixture is applied on the silicon crystal and the terahertz response is measured in time. This time dependences are analyzed to find time constants for mathematical description of the glue kinetics. Further, the investigated samples were analyzed using light microscopy and Raman spectroscopy for description of the structures and compositions.
ISSN:1866-6892
1866-6906
DOI:10.1007/s10762-016-0295-4