A head-to-head comparison between CT- and IVUS-derived coronary blood flow models

Abstract The goal of this work is to compare coronary hemodynamics as predicted by computational blood flow models derived from two imaging modalities: coronary computed tomography angiography (CCTA) and intravascular ultrasound integrated with angiography (IVUS). Criteria to define boundary conditi...

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Bibliographic Details
Published in:Journal of biomechanics 2017-01, Vol.51, p.65-76
Main Authors: Bulant, C.A, Blanco, P.J, Maso Talou, G.D, Bezerra, C. Guedes, Lemos, P.A, Feijóo, R.A
Format: Article
Language:English
Subjects:
Aged
Angiography
Bias
Blood flow
Blood vessels
Boundary conditions
Computed tomography
Coronary Angiography
Coronary blood flow
Coronary Circulation
Coronary vessels
Coronary Vessels - physiology
Female
Fractional flow reserve
Fractional Flow Reserve, Myocardial
Heart - physiology
Heart rate
Hemodynamics
Humans
Intravascular ultrasound
Male
Mathematical models
Medical imaging
Middle Aged
Models, Cardiovascular
Patients
Physical Medicine and Rehabilitation
Predictions
Reserves
Simulation
Standard deviation
Statistical analysis
Studies
Tomography, X-Ray Computed
Ultrasonography
Veins & arteries
Wall shear stress
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Summary:Abstract The goal of this work is to compare coronary hemodynamics as predicted by computational blood flow models derived from two imaging modalities: coronary computed tomography angiography (CCTA) and intravascular ultrasound integrated with angiography (IVUS). Criteria to define boundary conditions are proposed to overcome the dissimilar anatomical definition delivered by both modalities. The strategy to define boundary conditions is novel in the present context, and naturally accounts for the flow redistribution induced by the resistance of coronary vessels. Hyperemic conditions are assumed to assess model predictions under stressed hemodynamic environments similar to those encountered in Fractional Flow Reserve (FFR) calculations. As results, it was found that CCTA models predict larger pressure drops, higher average blood velocity and smaller FFR. Concerning the flow rate at distal locations in the major vessels of interest, it was found that CCTA predicted smaller flow than IVUS, which is a consequence of a larger sensitivity of CCTA models to coronary steal phenomena. Comparisons to in-vivo measurements of FFR are shown.
ISSN:0021-9290
1873-2380
DOI:10.1016/j.jbiomech.2016.11.070