PEG Grafted-Nanodiamonds for the Delivery of Gemcitabine

Carboxyl end‐functionalized poly[poly(ethylene glycol) methyl ether methacrylate] [P(PEGMEMA)] and its block copolymer with gemcitabine substituted poly(N‐hydroxysuccinimide methacrylate) [PGem‐block‐P(PEGMEMA)] are synthesized via reversible addition‐fragmentation transfer (RAFT) polymerization. Th...

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Bibliographic Details
Published in:Macromolecular rapid communications. 2016-12, Vol.37 (24), p.2023-2029
Main Authors: Lu, Mingxia, Wang, Yu-Kai, Zhao, Jiacheng, Lu, Hongxu, Stenzel, Martina H., Xiao, Pu
Format: Article
Language:English
Subjects:
Addition polymerization
Attenuation
Block copolymers
Cell Line, Tumor
Chemical synthesis
Cytotoxicity
Deoxycytidine - analogs & derivatives
Deoxycytidine - chemistry
Deoxycytidine - pharmacokinetics
Deoxycytidine - pharmacology
Diamonds
drug delivery
Drug delivery systems
Drug Delivery Systems - methods
Ethers
Fragmentation
Gemcitabine
Glycols
Grafting
Humans
Infrared analysis
Infrared radiation
Infrared spectroscopy
Light scattering
nanodiamonds
Nanodiamonds - chemistry
Nanostructure
pancreatic cancer
Pancreatic carcinoma
Pancreatic Neoplasms
Pancreatic Neoplasms - drug therapy
Pancreatic Neoplasms - metabolism
Photon correlation spectroscopy
Polyethylene glycol
Polyethylene Glycols - chemistry
Polymerization
Polymers
Reflectance
Spectroscopic analysis
Spectroscopy
Thermogravimetric analysis
Toxicity
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Summary:Carboxyl end‐functionalized poly[poly(ethylene glycol) methyl ether methacrylate] [P(PEGMEMA)] and its block copolymer with gemcitabine substituted poly(N‐hydroxysuccinimide methacrylate) [PGem‐block‐P(PEGMEMA)] are synthesized via reversible addition‐fragmentation transfer (RAFT) polymerization. Then, two polymers are grafted onto the surface of amine‐functionalized nanodiamonds to obtain [P(PEGMEMA)]‐grafted nanodiamonds (ND‐PEG) and [PGem‐block‐P(PEGMEMA)]‐grafted nanodiamonds (ND‐PF). Gemcitabine is physically absorbed to ND‐PEG to produce ND‐PEG (Gem). Two polymer‐grafted nanodiamonds (i.e., with physically absorbed gemcitabine ND‐PEG (Gem) and with chemically conjugated gemcitabine ND‐PF) are characterized using attenuated total reflectance infrared spectroscopy, dynamic light scattering, and thermogravimetric analysis. The drug release, cytotoxicity (to seed human pancreatic carcinoma AsPC‐1 cells), and cellular uptake of ND‐PEG (Gem) and ND‐PF are also investigated. Nanodiamonds grafted with block copolymer of poly[poly(ethylene glycol) methyl ether methacrylate and gemcitabine substituted poly(N‐hydroxysuccinimide methacrylate) can be used as suitable theragnostic nanoparticles for gemcitabine.
ISSN:1022-1336
1521-3927
DOI:10.1002/marc.201600344