Cold physical plasma selects for specific T helper cell subsets with distinct cells surface markers in a caspase-dependent and NF-[kappa]B-independent manner

Exposure to cold physical plasma has been proposed to be of therapeutical value in oncology via the generation of a number of biologically relevant redox-active molecules. Cancer cells can be recognized and eliminated by cells of the immune system, and accordingly many tumors are populated with thes...

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Bibliographic Details
Published in:Plasma processes and polymers 2016-12, Vol.13 (12), p.1144-1150
Main Authors: Bekeschus, Sander, Rodder, Katrin, Schmidt, Anke, Stope, Matthias B, von Woedtke, Thomas, Miller, Vandana, Fridman, Alexander, Weltmann, Klaus-Dieter, Masur, Kai, Metelmann, Hans-Robert, Wende, Kristian, Hasse, Sybille
Format: Article
Language:English
Subjects:
Antigens
Argon plasma
Atmospheric pressure
Barometric pressure
Cancer
Cold pressing
Lymphocytes
Plasma
T cell receptors
Tumors
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Summary:Exposure to cold physical plasma has been proposed to be of therapeutical value in oncology via the generation of a number of biologically relevant redox-active molecules. Cancer cells can be recognized and eliminated by cells of the immune system, and accordingly many tumors are populated with these cells, among them T helper cells (TH cells). These lymphocyte population is crucial for effector immune responses against tumor antigens, in response to immunogenic cell death in malignant cells. However, a number of TH populations exists, each having distinct phenotypical features. Using a cold atmospheric pressure argon plasma jet, its redox activity was tested in different TH cell subpopulations to better understand the immunological consequences of potential antitumor plasma treatments in vivo.
ISSN:1612-8850
1612-8869
DOI:10.1002/ppap.201600080