Harnessing ester bond chemistry for protein ligation

The hydrolysis potential of ester bonds in covalently cross-linking proteins is captured in our novel protein ligation technology. This new type of "molecular superglue" based on the spontaneously-formed Thr-Gln ester bonds found in cell-surface adhesins, affords a unique mechanism to both...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2017, Vol.53 (9), p.1502-1505
Main Authors: Young, P G, Yosaatmadja, Y, Harris, P W R, Leung, I K H, Baker, E N, Squire, C J
Format: Article
Language:English
Subjects:
Adhesive bonding
Chemical bonds
Covalence
Dismantling
Esters
Hydrolysis
Nanomaterials
Proteins
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Summary:The hydrolysis potential of ester bonds in covalently cross-linking proteins is captured in our novel protein ligation technology. This new type of "molecular superglue" based on the spontaneously-formed Thr-Gln ester bonds found in cell-surface adhesins, affords a unique mechanism to both rationally assemble and disassemble complex protein nanomaterials.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc09899a