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Spanish version of the Mattis Dementia Rating Scale‐2 for early detection of Alzheimer's disease and mild cognitive impairment
Objective We aimed to analyse the clinical utility of the Mattis Dementia Rating Scale (MDRS‐2) for early detection of Alzheimer's disease (AD) and amnestic mild cognitive impairment (MCI) in a sample of Spanish older adults. Methods A total of 125 participants (age = 75.12 ± 6.83, years of edu...
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| Published in: | International journal of geriatric psychiatry 2018-06, Vol.33 (6), p.832-840 |
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| Main Authors: | , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c3497-6ca3c0bc8c5dcd822708c1cdea8bae8f000f754760c12d5b69c1a6285e5733c13 |
| container_end_page | 840 |
| container_issue | 6 |
| container_start_page | 832 |
| container_title | International journal of geriatric psychiatry |
| container_volume | 33 |
| creator | Boycheva, Elina Contador, Israel Fernández‐Calvo, Bernardino Ramos‐Campos, Francisco Puertas‐Martín, Verónica Villarejo‐Galende, Alberto Bermejo‐Pareja, Félix |
| description | Objective
We aimed to analyse the clinical utility of the Mattis Dementia Rating Scale (MDRS‐2) for early detection of Alzheimer's disease (AD) and amnestic mild cognitive impairment (MCI) in a sample of Spanish older adults.
Methods
A total of 125 participants (age = 75.12 ± 6.83, years of education =7.08 ± 3.57) were classified in three diagnostic groups: 45 patients with mild AD, 37 with amnestic MCI—single and multiple domain and 43 cognitively healthy controls (HCs). Reliability, criterion validity and diagnostic accuracy of the MDRS‐2 (total and subscales) were analysed. The MDRS‐2 scores, adjusted by socio‐demographic characteristics, were calculated through hierarchical multiple regression analysis.
Results
The global scale had adequate reliability (α = 0.736) and good criterion validity (r = 0.760, p |
| doi_str_mv | 10.1002/gps.4707 |
| format | article |
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We aimed to analyse the clinical utility of the Mattis Dementia Rating Scale (MDRS‐2) for early detection of Alzheimer's disease (AD) and amnestic mild cognitive impairment (MCI) in a sample of Spanish older adults.
Methods
A total of 125 participants (age = 75.12 ± 6.83, years of education =7.08 ± 3.57) were classified in three diagnostic groups: 45 patients with mild AD, 37 with amnestic MCI—single and multiple domain and 43 cognitively healthy controls (HCs). Reliability, criterion validity and diagnostic accuracy of the MDRS‐2 (total and subscales) were analysed. The MDRS‐2 scores, adjusted by socio‐demographic characteristics, were calculated through hierarchical multiple regression analysis.
Results
The global scale had adequate reliability (α = 0.736) and good criterion validity (r = 0.760, p < .001) with the Mini‐Mental State Examination. The optimal cut‐off point between AD patients and HCs was 124 (sensitivity [Se] = 97% and specificity [Sp] = 95%), whereas 131 (Se = 89%, Sp = 81%) was the optimal cut‐off point between MCI and HCs. An optimal cut‐off point of 123 had good Se (0.97), but poor Sp (0.56) to differentiate AD and MCI groups. The Memory and Initiation/Perseveration subscales had the highest discriminative capacity between the groups.
Conclusions
The MDRS‐2 is a reliable and valid instrument for the assessment of cognitive impairment in Spanish older adults. In particular, optimal capacity emerged for the detection of early AD and MCI. Copyright © 2017 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0885-6230</identifier><identifier>EISSN: 1099-1166</identifier><identifier>DOI: 10.1002/gps.4707</identifier><identifier>PMID: 28332732</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Aged ; Aged, 80 and over ; Alzheimer Disease - diagnosis ; Alzheimer Disease - psychology ; Alzheimer's disease ; clinical validity ; Cognitive ability ; Cognitive Dysfunction - diagnosis ; Cognitive Dysfunction - psychology ; Dementia ; Dementia disorders ; early detection ; Early Diagnosis ; Female ; Geriatric psychiatry ; Hispanic Americans ; Humans ; Male ; Memory ; Mental Status and Dementia Tests ; Middle Aged ; mild cognitive impairment ; Multiple regression analysis ; Neurodegenerative diseases ; neuropsychological assessment ; older adults ; Older people ; Psychometrics - standards ; Regression Analysis ; Reproducibility of Results ; Sensitivity and Specificity</subject><ispartof>International journal of geriatric psychiatry, 2018-06, Vol.33 (6), p.832-840</ispartof><rights>Copyright © 2017 John Wiley & Sons, Ltd.</rights><rights>Copyright © 2018 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3497-6ca3c0bc8c5dcd822708c1cdea8bae8f000f754760c12d5b69c1a6285e5733c13</citedby><cites>FETCH-LOGICAL-c3497-6ca3c0bc8c5dcd822708c1cdea8bae8f000f754760c12d5b69c1a6285e5733c13</cites><orcidid>0000-0002-9506-8491 ; 0000-0001-8080-5578</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28332732$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boycheva, Elina</creatorcontrib><creatorcontrib>Contador, Israel</creatorcontrib><creatorcontrib>Fernández‐Calvo, Bernardino</creatorcontrib><creatorcontrib>Ramos‐Campos, Francisco</creatorcontrib><creatorcontrib>Puertas‐Martín, Verónica</creatorcontrib><creatorcontrib>Villarejo‐Galende, Alberto</creatorcontrib><creatorcontrib>Bermejo‐Pareja, Félix</creatorcontrib><title>Spanish version of the Mattis Dementia Rating Scale‐2 for early detection of Alzheimer's disease and mild cognitive impairment</title><title>International journal of geriatric psychiatry</title><addtitle>Int J Geriatr Psychiatry</addtitle><description>Objective
We aimed to analyse the clinical utility of the Mattis Dementia Rating Scale (MDRS‐2) for early detection of Alzheimer's disease (AD) and amnestic mild cognitive impairment (MCI) in a sample of Spanish older adults.
Methods
A total of 125 participants (age = 75.12 ± 6.83, years of education =7.08 ± 3.57) were classified in three diagnostic groups: 45 patients with mild AD, 37 with amnestic MCI—single and multiple domain and 43 cognitively healthy controls (HCs). Reliability, criterion validity and diagnostic accuracy of the MDRS‐2 (total and subscales) were analysed. The MDRS‐2 scores, adjusted by socio‐demographic characteristics, were calculated through hierarchical multiple regression analysis.
Results
The global scale had adequate reliability (α = 0.736) and good criterion validity (r = 0.760, p < .001) with the Mini‐Mental State Examination. The optimal cut‐off point between AD patients and HCs was 124 (sensitivity [Se] = 97% and specificity [Sp] = 95%), whereas 131 (Se = 89%, Sp = 81%) was the optimal cut‐off point between MCI and HCs. An optimal cut‐off point of 123 had good Se (0.97), but poor Sp (0.56) to differentiate AD and MCI groups. The Memory and Initiation/Perseveration subscales had the highest discriminative capacity between the groups.
Conclusions
The MDRS‐2 is a reliable and valid instrument for the assessment of cognitive impairment in Spanish older adults. In particular, optimal capacity emerged for the detection of early AD and MCI. Copyright © 2017 John Wiley & Sons, Ltd.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer Disease - psychology</subject><subject>Alzheimer's disease</subject><subject>clinical validity</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - diagnosis</subject><subject>Cognitive Dysfunction - psychology</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>early detection</subject><subject>Early Diagnosis</subject><subject>Female</subject><subject>Geriatric psychiatry</subject><subject>Hispanic Americans</subject><subject>Humans</subject><subject>Male</subject><subject>Memory</subject><subject>Mental Status and Dementia Tests</subject><subject>Middle Aged</subject><subject>mild cognitive impairment</subject><subject>Multiple regression analysis</subject><subject>Neurodegenerative diseases</subject><subject>neuropsychological assessment</subject><subject>older adults</subject><subject>Older people</subject><subject>Psychometrics - standards</subject><subject>Regression Analysis</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><issn>0885-6230</issn><issn>1099-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kc1OGzEQx60KVFJaqU-ALHFoLwv-yNreY0T5qAQCkfZsee3ZxNF-YTugcOIReEaehE1JQULiNIf5zU8z80foOyUHlBB2OOvjwVgS-QmNKCmKjFIhttCIKJVngnGyg77EuCBk6FH1Ge0wxTmTnI3Qw7Q3rY9zfAsh-q7FXYXTHPCFSclH_AsaaJM3-Nok387w1Joanh4eGa66gMGEeoUdJLBpMzup7-fgGwg_InY-gomATetw42uHbTdrffK3gH3TGx_W7q9ouzJ1hG-buov-nhz_OTrLzi9Pfx9NzjPLx4XMhDXcktIqmzvrFGOSKEutA6NKA6oabqtkPpaCWMpcXorCUiOYyiGXnFvKd9HPF28fupslxKQbHy3UtWmhW0ZNlSLDC2khB3T_HbrolqEdttOMcC6kYGz8JrShizFApfvgGxNWmhK9TkUPqeh1KgO6txEuywbcK_g_hgHIXoA7X8PqQ5E-vZr-Ez4D1teXfA</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Boycheva, Elina</creator><creator>Contador, Israel</creator><creator>Fernández‐Calvo, Bernardino</creator><creator>Ramos‐Campos, Francisco</creator><creator>Puertas‐Martín, Verónica</creator><creator>Villarejo‐Galende, Alberto</creator><creator>Bermejo‐Pareja, Félix</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9506-8491</orcidid><orcidid>https://orcid.org/0000-0001-8080-5578</orcidid></search><sort><creationdate>201806</creationdate><title>Spanish version of the Mattis Dementia Rating Scale‐2 for early detection of Alzheimer's disease and mild cognitive impairment</title><author>Boycheva, Elina ; Contador, Israel ; Fernández‐Calvo, Bernardino ; Ramos‐Campos, Francisco ; Puertas‐Martín, Verónica ; Villarejo‐Galende, Alberto ; Bermejo‐Pareja, Félix</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3497-6ca3c0bc8c5dcd822708c1cdea8bae8f000f754760c12d5b69c1a6285e5733c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer Disease - psychology</topic><topic>Alzheimer's disease</topic><topic>clinical validity</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - diagnosis</topic><topic>Cognitive Dysfunction - psychology</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>early detection</topic><topic>Early Diagnosis</topic><topic>Female</topic><topic>Geriatric psychiatry</topic><topic>Hispanic Americans</topic><topic>Humans</topic><topic>Male</topic><topic>Memory</topic><topic>Mental Status and Dementia Tests</topic><topic>Middle Aged</topic><topic>mild cognitive impairment</topic><topic>Multiple regression analysis</topic><topic>Neurodegenerative diseases</topic><topic>neuropsychological assessment</topic><topic>older adults</topic><topic>Older people</topic><topic>Psychometrics - standards</topic><topic>Regression Analysis</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boycheva, Elina</creatorcontrib><creatorcontrib>Contador, Israel</creatorcontrib><creatorcontrib>Fernández‐Calvo, Bernardino</creatorcontrib><creatorcontrib>Ramos‐Campos, Francisco</creatorcontrib><creatorcontrib>Puertas‐Martín, Verónica</creatorcontrib><creatorcontrib>Villarejo‐Galende, Alberto</creatorcontrib><creatorcontrib>Bermejo‐Pareja, Félix</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of geriatric psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boycheva, Elina</au><au>Contador, Israel</au><au>Fernández‐Calvo, Bernardino</au><au>Ramos‐Campos, Francisco</au><au>Puertas‐Martín, Verónica</au><au>Villarejo‐Galende, Alberto</au><au>Bermejo‐Pareja, Félix</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spanish version of the Mattis Dementia Rating Scale‐2 for early detection of Alzheimer's disease and mild cognitive impairment</atitle><jtitle>International journal of geriatric psychiatry</jtitle><addtitle>Int J Geriatr Psychiatry</addtitle><date>2018-06</date><risdate>2018</risdate><volume>33</volume><issue>6</issue><spage>832</spage><epage>840</epage><pages>832-840</pages><issn>0885-6230</issn><eissn>1099-1166</eissn><abstract>Objective
We aimed to analyse the clinical utility of the Mattis Dementia Rating Scale (MDRS‐2) for early detection of Alzheimer's disease (AD) and amnestic mild cognitive impairment (MCI) in a sample of Spanish older adults.
Methods
A total of 125 participants (age = 75.12 ± 6.83, years of education =7.08 ± 3.57) were classified in three diagnostic groups: 45 patients with mild AD, 37 with amnestic MCI—single and multiple domain and 43 cognitively healthy controls (HCs). Reliability, criterion validity and diagnostic accuracy of the MDRS‐2 (total and subscales) were analysed. The MDRS‐2 scores, adjusted by socio‐demographic characteristics, were calculated through hierarchical multiple regression analysis.
Results
The global scale had adequate reliability (α = 0.736) and good criterion validity (r = 0.760, p < .001) with the Mini‐Mental State Examination. The optimal cut‐off point between AD patients and HCs was 124 (sensitivity [Se] = 97% and specificity [Sp] = 95%), whereas 131 (Se = 89%, Sp = 81%) was the optimal cut‐off point between MCI and HCs. An optimal cut‐off point of 123 had good Se (0.97), but poor Sp (0.56) to differentiate AD and MCI groups. The Memory and Initiation/Perseveration subscales had the highest discriminative capacity between the groups.
Conclusions
The MDRS‐2 is a reliable and valid instrument for the assessment of cognitive impairment in Spanish older adults. In particular, optimal capacity emerged for the detection of early AD and MCI. Copyright © 2017 John Wiley & Sons, Ltd.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28332732</pmid><doi>10.1002/gps.4707</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-9506-8491</orcidid><orcidid>https://orcid.org/0000-0001-8080-5578</orcidid></addata></record> |
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| ispartof | International journal of geriatric psychiatry, 2018-06, Vol.33 (6), p.832-840 |
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| subjects | Aged Aged, 80 and over Alzheimer Disease - diagnosis Alzheimer Disease - psychology Alzheimer's disease clinical validity Cognitive ability Cognitive Dysfunction - diagnosis Cognitive Dysfunction - psychology Dementia Dementia disorders early detection Early Diagnosis Female Geriatric psychiatry Hispanic Americans Humans Male Memory Mental Status and Dementia Tests Middle Aged mild cognitive impairment Multiple regression analysis Neurodegenerative diseases neuropsychological assessment older adults Older people Psychometrics - standards Regression Analysis Reproducibility of Results Sensitivity and Specificity |
| title | Spanish version of the Mattis Dementia Rating Scale‐2 for early detection of Alzheimer's disease and mild cognitive impairment |
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