Polybrominated Dibenzo-p-dioxins, Dibenzofurans, and Diphenyl Ethers in Japanese Human Adipose Tissue

Human adipose samples collected in Tokyo, Japan in 1970 and 2000 were analyzed for the presence of polybrominated dibenzo-p-dioxins (PBDDs), dibenzofurans (PBDFs), and diphenyl ethers (PBDEs), and the concentrations in the two groups were compared. As far as we know, the concentrations of the PBDD/F...

Full description

Saved in:
Bibliographic Details
Published in:Environmental science & technology 2003-03, Vol.37 (5), p.817-821
Main Authors: Choi, Jae-won, Fujimaki, Susumu, Kitamura, Kimiyoshi, Hashimoto, Shunji, Ito, Hiroyasu, Suzuki, Noriyuki, Sakai, Shin-ichi, Morita, Masatoshi
Format: Article
Language:English
Subjects:
Adipose Tissue - chemistry
Adult
Benzofurans - pharmacokinetics
Biological and medical sciences
Body fat
Contamination
Dibenzofurans, Polychlorinated
Dioxins
Dioxins - pharmacokinetics
Environmental Exposure
Environmental Monitoring
Environmental Pollutants - pharmacokinetics
Environmental pollutants toxicology
Female
General aspects
Humans
Japan
Medical sciences
Middle Aged
PCB
Polybrominated Biphenyls - pharmacokinetics
Polychlorinated biphenyls
Reference Values
Tissue Distribution
Toxicology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Human adipose samples collected in Tokyo, Japan in 1970 and 2000 were analyzed for the presence of polybrominated dibenzo-p-dioxins (PBDDs), dibenzofurans (PBDFs), and diphenyl ethers (PBDEs), and the concentrations in the two groups were compared. As far as we know, the concentrations of the PBDD/Fs in adipose tissue from the general Japanese population are reported for the first time. Three PBDD/F congeners were found in the following adipose tissues:  2,3,7,8-TeBDD, 2,3,7,8-TeBDF, and 2,3,4,7,8-PeBDF. The median concentrations (ranges) of three PBDD/Fs in 1970 and 2000 were 5.1 (3.4−8.3) and 3.4 (1.9−5.3) pg/g lipid wt (l.w.), respectively. For PBDEs, seven PBDE congeners were determined in the following samples:  2,4,4‘-tribromodiphenyl ether (BDE-28), 2,2‘,4,4‘-tetrabromodiphenyl ether (BDE-47), 2,2‘,4,4‘,5-pentabromodiphenyl ether (BDE-99), 2,2‘,4,4‘,6-pentabromodiphenyl ether (BDE-100), 2,2‘,4,4‘,5,5‘-hexabromodiphenyl ether (BDE-153), 2,2‘,4,4‘,5‘,6-hexabromodiphenyl ether (BDE-154), and 2,2‘,3,4,4‘,5‘,6-heptabromodiphenyl ether (BDE-183). Median concentrations (ranges) of PBDEs showed a significant increase from 29.2 (6.8−78.4) pg/g l.w. in 1970 to 1288 (466−2,753) pg/g l.w. in 2000. BDE-47, the major congener of PBDEs, was 56.2% and 35.6% of the total in 1970 and 2000, respectively, whereas the BDE-153 was
ISSN:0013-936X
1520-5851
DOI:10.1021/es0258780